Advanced paternal age and parental history of schizophrenia

Brian J Miller, Jaana Suvisaari, Jouko Miettunen, Marjo Riitta Järvelin, Jari Haukka, Antti Tanskanen, Jouko Lönnqvist, Matti Isohanni, Brian Kirkpatrick

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Introduction: Advanced paternal age (APA) is a risk factor for nonaffective psychosis (NAP) in the offspring, although the mechanism(s) of this association are not clear. The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the "de novo mutation" hypothesis for the association between APA and NAP. Methods: Using binary logistic regression, the association between APA and parental history of schizophrenia in the offspring, considering maternal and paternal history separately, was examined in 1) all persons with NAP born in Finland between 1950 and 1969 (Finnish NAP Cohort, n = 13,712), and 2) members of the Northern Finland 1966 Birth Cohort (NFBC 1966, n = 10,224), a general population birth cohort. Results: In the Finnish NAP Cohort, having a mother with schizophrenia was associated with APA (Odds Ratio [OR] for linear trend = 1.20, 95% confidence interval 1.12-1.29, p < 0.01). In the NFBC 1966 sample, having a mother with schizophrenia was associated with APA at the trend level (OR = 1.14, 0.99-1.31, p = 0.07). By contrast, there was no association between having a father with schizophrenia and APA. Discussion: In both a general population cohort and a birth cohort of subjects with nonaffective psychosis, APA was associated with maternal, but not paternal, schizophrenia. These findings suggest that increased genetic risk from the mother may explain the association between APA and nonaffective psychosis, and argue against the "de novo mutation" hypothesis.

Original languageEnglish (US)
Pages (from-to)125-132
Number of pages8
JournalSchizophrenia Research
Volume133
Issue number1-3
DOIs
StatePublished - Dec 1 2011

Fingerprint

Paternal Age
Schizophrenia
Psychotic Disorders
Mothers
Parturition
Finland
Odds Ratio
Mutation
Fathers
Population
Logistic Models
History
Confidence Intervals

Keywords

  • Epidemiology
  • Family history
  • Paternal age
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Miller, B. J., Suvisaari, J., Miettunen, J., Järvelin, M. R., Haukka, J., Tanskanen, A., ... Kirkpatrick, B. (2011). Advanced paternal age and parental history of schizophrenia. Schizophrenia Research, 133(1-3), 125-132. https://doi.org/10.1016/j.schres.2011.08.013

Advanced paternal age and parental history of schizophrenia. / Miller, Brian J; Suvisaari, Jaana; Miettunen, Jouko; Järvelin, Marjo Riitta; Haukka, Jari; Tanskanen, Antti; Lönnqvist, Jouko; Isohanni, Matti; Kirkpatrick, Brian.

In: Schizophrenia Research, Vol. 133, No. 1-3, 01.12.2011, p. 125-132.

Research output: Contribution to journalArticle

Miller, BJ, Suvisaari, J, Miettunen, J, Järvelin, MR, Haukka, J, Tanskanen, A, Lönnqvist, J, Isohanni, M & Kirkpatrick, B 2011, 'Advanced paternal age and parental history of schizophrenia', Schizophrenia Research, vol. 133, no. 1-3, pp. 125-132. https://doi.org/10.1016/j.schres.2011.08.013
Miller BJ, Suvisaari J, Miettunen J, Järvelin MR, Haukka J, Tanskanen A et al. Advanced paternal age and parental history of schizophrenia. Schizophrenia Research. 2011 Dec 1;133(1-3):125-132. https://doi.org/10.1016/j.schres.2011.08.013
Miller, Brian J ; Suvisaari, Jaana ; Miettunen, Jouko ; Järvelin, Marjo Riitta ; Haukka, Jari ; Tanskanen, Antti ; Lönnqvist, Jouko ; Isohanni, Matti ; Kirkpatrick, Brian. / Advanced paternal age and parental history of schizophrenia. In: Schizophrenia Research. 2011 ; Vol. 133, No. 1-3. pp. 125-132.
@article{cab0c023f6be4c3995985146f70dc388,
title = "Advanced paternal age and parental history of schizophrenia",
abstract = "Introduction: Advanced paternal age (APA) is a risk factor for nonaffective psychosis (NAP) in the offspring, although the mechanism(s) of this association are not clear. The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the {"}de novo mutation{"} hypothesis for the association between APA and NAP. Methods: Using binary logistic regression, the association between APA and parental history of schizophrenia in the offspring, considering maternal and paternal history separately, was examined in 1) all persons with NAP born in Finland between 1950 and 1969 (Finnish NAP Cohort, n = 13,712), and 2) members of the Northern Finland 1966 Birth Cohort (NFBC 1966, n = 10,224), a general population birth cohort. Results: In the Finnish NAP Cohort, having a mother with schizophrenia was associated with APA (Odds Ratio [OR] for linear trend = 1.20, 95{\%} confidence interval 1.12-1.29, p < 0.01). In the NFBC 1966 sample, having a mother with schizophrenia was associated with APA at the trend level (OR = 1.14, 0.99-1.31, p = 0.07). By contrast, there was no association between having a father with schizophrenia and APA. Discussion: In both a general population cohort and a birth cohort of subjects with nonaffective psychosis, APA was associated with maternal, but not paternal, schizophrenia. These findings suggest that increased genetic risk from the mother may explain the association between APA and nonaffective psychosis, and argue against the {"}de novo mutation{"} hypothesis.",
keywords = "Epidemiology, Family history, Paternal age, Schizophrenia",
author = "Miller, {Brian J} and Jaana Suvisaari and Jouko Miettunen and J{\"a}rvelin, {Marjo Riitta} and Jari Haukka and Antti Tanskanen and Jouko L{\"o}nnqvist and Matti Isohanni and Brian Kirkpatrick",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.schres.2011.08.013",
language = "English (US)",
volume = "133",
pages = "125--132",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Advanced paternal age and parental history of schizophrenia

AU - Miller, Brian J

AU - Suvisaari, Jaana

AU - Miettunen, Jouko

AU - Järvelin, Marjo Riitta

AU - Haukka, Jari

AU - Tanskanen, Antti

AU - Lönnqvist, Jouko

AU - Isohanni, Matti

AU - Kirkpatrick, Brian

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Introduction: Advanced paternal age (APA) is a risk factor for nonaffective psychosis (NAP) in the offspring, although the mechanism(s) of this association are not clear. The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the "de novo mutation" hypothesis for the association between APA and NAP. Methods: Using binary logistic regression, the association between APA and parental history of schizophrenia in the offspring, considering maternal and paternal history separately, was examined in 1) all persons with NAP born in Finland between 1950 and 1969 (Finnish NAP Cohort, n = 13,712), and 2) members of the Northern Finland 1966 Birth Cohort (NFBC 1966, n = 10,224), a general population birth cohort. Results: In the Finnish NAP Cohort, having a mother with schizophrenia was associated with APA (Odds Ratio [OR] for linear trend = 1.20, 95% confidence interval 1.12-1.29, p < 0.01). In the NFBC 1966 sample, having a mother with schizophrenia was associated with APA at the trend level (OR = 1.14, 0.99-1.31, p = 0.07). By contrast, there was no association between having a father with schizophrenia and APA. Discussion: In both a general population cohort and a birth cohort of subjects with nonaffective psychosis, APA was associated with maternal, but not paternal, schizophrenia. These findings suggest that increased genetic risk from the mother may explain the association between APA and nonaffective psychosis, and argue against the "de novo mutation" hypothesis.

AB - Introduction: Advanced paternal age (APA) is a risk factor for nonaffective psychosis (NAP) in the offspring, although the mechanism(s) of this association are not clear. The aim of this study was to examine whether later childbearing can be explained by parental schizophrenia, and in doing so, further evaluate the "de novo mutation" hypothesis for the association between APA and NAP. Methods: Using binary logistic regression, the association between APA and parental history of schizophrenia in the offspring, considering maternal and paternal history separately, was examined in 1) all persons with NAP born in Finland between 1950 and 1969 (Finnish NAP Cohort, n = 13,712), and 2) members of the Northern Finland 1966 Birth Cohort (NFBC 1966, n = 10,224), a general population birth cohort. Results: In the Finnish NAP Cohort, having a mother with schizophrenia was associated with APA (Odds Ratio [OR] for linear trend = 1.20, 95% confidence interval 1.12-1.29, p < 0.01). In the NFBC 1966 sample, having a mother with schizophrenia was associated with APA at the trend level (OR = 1.14, 0.99-1.31, p = 0.07). By contrast, there was no association between having a father with schizophrenia and APA. Discussion: In both a general population cohort and a birth cohort of subjects with nonaffective psychosis, APA was associated with maternal, but not paternal, schizophrenia. These findings suggest that increased genetic risk from the mother may explain the association between APA and nonaffective psychosis, and argue against the "de novo mutation" hypothesis.

KW - Epidemiology

KW - Family history

KW - Paternal age

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=81955167945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81955167945&partnerID=8YFLogxK

U2 - 10.1016/j.schres.2011.08.013

DO - 10.1016/j.schres.2011.08.013

M3 - Article

VL - 133

SP - 125

EP - 132

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

IS - 1-3

ER -