Advances and challenges in biomarker development for type 1 diabetes prediction and prevention using "omic" technologies

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Importance of the field: Biomarkers are essential for the identification of high-risk children as well as monitoring of prevention outcomes for type 1 diabetes (T1D). Areas covered in this review: This review discusses progress, opportunities and challenges in biomarker discovery and validation using high-throughput genomic, transcriptomic and proteomic technologies. The authors also suggest potential solutions to deal with the current challenges. What the reader will gain: Readers will gain an overview of the current status on T1D biomarkers, an integrated review of three "omic" technologies, their applications and limitations for biomarker discovery and validation, and a critical discussion of the major issues encountered in biomarker development. Take home message: Better biomarkers are still urgently needed for T1D prediction and prevention. The high-throughput omic technologies offer great opportunities but also face significant challenges that have to be solved before their potential for biomarker development is fully realized.

Original languageEnglish (US)
Pages (from-to)397-410
Number of pages14
JournalExpert Opinion on Medical Diagnostics
Volume4
Issue number5
DOIs
Publication statusPublished - Sep 1 2010

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Keywords

  • Biomarkers
  • Prediction
  • Prevention
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Molecular Medicine
  • Biochemistry, medical

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