Advances in Molecular biomarker for early diagnosis of Osteoarthritis

Akul Munjal, Santul Bapat, Daniel Hubbard, Monte Hunter, Ravindra Kolhe, Sadanand Fulzele

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Osteoarthritis (OA) is a chronic degenerative joint disease. The pathogenesis is poorly understood. What is known is that OA is characterized by imbalance in anabolic and catabolic gene expression in articular chondrocytes. This results in bone on bone articulations resulting in impaired mobility and joint pain. Although the cause of OA is unknown, comorbidities include: aging, obesity, and mechanical stress. Currently the only diagnostic modalities are radiology and physical examination, and early detection is rare. Biomarkers are quantifiable substances, and their presence can be suggestive of a certain phenomenon or disease. Biomarkers are popular for early diagnosis for pathological conditions in the fields of oncology, cardiology, and endocrinology. This review has systematically reviewed the literature about biomarkers in the field of OA, specifically protein, miRNA, and metabolic biomarkers found in the blood, urine, and synovial fluid.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalBiomolecular Concepts
Volume10
Issue number1
DOIs
StatePublished - 2019

Keywords

  • Biomarker
  • Diagnosis
  • Osteoarthritis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

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