Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults

Shaoyong Su, Xiaoling Wang, Kakota Gaston Kapuku, Frank A. Treiber, David M. Pollock, Gregory A Harshfield, William Vaughn McCall, Jennifer S. Pollock

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Growing evidence suggests that adverse childhood experiences (ACEs) increase the risks for coronary heart disease and hypertension in mid and late adulthood. We previously reported that early life stress induces a hyperreactive endothelin-dependent cardiovascular phenotype in a rat model. In the present study, we evaluated whether exposure to ACEs is associated with greater peripheral resistance, arterial stiffness, blood pressure, or elevated circulating endothelin-1 levels in humans. In 221 healthy adolescents and young adults (mean age, 21 years; range, 13-29 years), we found a graded association of ACE exposure with plasma endothelin-1 levels, of which on average 18% and 24% were higher in participants with 1 ACE and ≥2 ACEs, respectively, compared with those with no ACEs (P=0.001). Participants with moderate/severe exposure to ACEs (≥2 ACEs) had significantly higher total peripheral resistance index (+12%), diastolic blood pressure (+5%), and pulse wave velocity (+9%) compared with those who were not exposed. These associations were independent of age, race, sex, body mass index, and childhood socioeconomic status. Our results indicate that early life stress promotes cardiovascular disease risk, specifically detrimental vascular and cardiac function, detectable in young adulthood.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalHypertension
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Endothelin-1
Psychological Stress
Vascular Resistance
Young Adult
Hemodynamics
Blood Pressure
Pulse Wave Analysis
Vascular Stiffness
Endothelins
Social Class
Coronary Disease
Blood Vessels
Arterial Pressure
Body Mass Index
Cardiovascular Diseases
Hypertension
Phenotype

Keywords

  • adverse childhood experiences
  • blood pressure
  • endothelin-1
  • pulse wave analysis
  • vascular resistance

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults",
abstract = "Growing evidence suggests that adverse childhood experiences (ACEs) increase the risks for coronary heart disease and hypertension in mid and late adulthood. We previously reported that early life stress induces a hyperreactive endothelin-dependent cardiovascular phenotype in a rat model. In the present study, we evaluated whether exposure to ACEs is associated with greater peripheral resistance, arterial stiffness, blood pressure, or elevated circulating endothelin-1 levels in humans. In 221 healthy adolescents and young adults (mean age, 21 years; range, 13-29 years), we found a graded association of ACE exposure with plasma endothelin-1 levels, of which on average 18{\%} and 24{\%} were higher in participants with 1 ACE and ≥2 ACEs, respectively, compared with those with no ACEs (P=0.001). Participants with moderate/severe exposure to ACEs (≥2 ACEs) had significantly higher total peripheral resistance index (+12{\%}), diastolic blood pressure (+5{\%}), and pulse wave velocity (+9{\%}) compared with those who were not exposed. These associations were independent of age, race, sex, body mass index, and childhood socioeconomic status. Our results indicate that early life stress promotes cardiovascular disease risk, specifically detrimental vascular and cardiac function, detectable in young adulthood.",
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author = "Shaoyong Su and Xiaoling Wang and Kapuku, {Kakota Gaston} and Treiber, {Frank A.} and Pollock, {David M.} and Harshfield, {Gregory A} and McCall, {William Vaughn} and Pollock, {Jennifer S.}",
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AU - Su, Shaoyong

AU - Wang, Xiaoling

AU - Kapuku, Kakota Gaston

AU - Treiber, Frank A.

AU - Pollock, David M.

AU - Harshfield, Gregory A

AU - McCall, William Vaughn

AU - Pollock, Jennifer S.

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