African Americans with Barrett's esophagus are less likely to have dysplasia at biopsy

Joe E. Khoury, Sian Chisholm, M. Mazen Jamal, Carlos Palacio, Sunitha Pudhota, Kenneth J Vega

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Barrett's Esophagus (BE) is a pre-malignant condition. Limited data on BE dysplasia prevalence exists among United States ethnic groups. Aim: The purpose of this study was to determine if the frequency of BE with dysplasia varies among the major ethnic groups presenting to our institution. Methods: The University of Florida-Jacksonville endoscopy database was searched for all cases of endoscopic BE from September 2002 to August 2007. Histologic BE was diagnosed if salmon colored esophageal mucosa was endoscopically seen at least 1 cm above the top of the gastric folds and biopsy revealed intestinal metaplasia with Alcian blue-containing goblet cells. Demographic data collected for all included: age at diagnosis, ethnicity, sex, previous history of esophageal reflux, atypical manifestations (chronic cough, aspiration), endoscopic length of BE, presence or absence of hiatal hernia, esophageal stricture or ulcer, and presence or absence of dysplasia. Results: Salmon colored esophageal mucosa was observed in 405 of 7,308 patients (5.5%) and histologically confirmed in 115 of 405 patients (28%) reflecting an overall prevalence of BE of 115/7308 (1.6%) in this cohort. Ethnic distribution of histologic BE patients was as follows: 95 (83%) non-Hispanic white (nHw), 16 (14%) African American (AA) and 4 (3%) other. Long segment BE (LSBE) and any form of dysplasia was observed less frequently in AA than nHw (LSBE: 12% vs. 26% and dysplasia: 0% vs. 7%). Conclusions: LSBE and dysplasia are less frequent in AA than nHw. Studies in AA with BE may illustrate factors limiting dysplasia and LSBE risk.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalDigestive Diseases and Sciences
Volume57
Issue number2
DOIs
StatePublished - Feb 1 2012

Fingerprint

Barrett Esophagus
African Americans
Biopsy
Salmon
Ethnic Groups
Esophageal Stenosis
Alcian Blue
Hiatal Hernia
Goblet Cells
Metaplasia
Gastroesophageal Reflux
Cough
Endoscopy
Ulcer
Stomach
Demography
Databases

Keywords

  • African American
  • Barrett's esophagus
  • Demographics
  • Dysplasia
  • Ethnicity

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

African Americans with Barrett's esophagus are less likely to have dysplasia at biopsy. / Khoury, Joe E.; Chisholm, Sian; Mazen Jamal, M.; Palacio, Carlos; Pudhota, Sunitha; Vega, Kenneth J.

In: Digestive Diseases and Sciences, Vol. 57, No. 2, 01.02.2012, p. 419-423.

Research output: Contribution to journalArticle

Khoury, Joe E. ; Chisholm, Sian ; Mazen Jamal, M. ; Palacio, Carlos ; Pudhota, Sunitha ; Vega, Kenneth J. / African Americans with Barrett's esophagus are less likely to have dysplasia at biopsy. In: Digestive Diseases and Sciences. 2012 ; Vol. 57, No. 2. pp. 419-423.
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AU - Chisholm, Sian

AU - Mazen Jamal, M.

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AU - Pudhota, Sunitha

AU - Vega, Kenneth J

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N2 - Background: Barrett's Esophagus (BE) is a pre-malignant condition. Limited data on BE dysplasia prevalence exists among United States ethnic groups. Aim: The purpose of this study was to determine if the frequency of BE with dysplasia varies among the major ethnic groups presenting to our institution. Methods: The University of Florida-Jacksonville endoscopy database was searched for all cases of endoscopic BE from September 2002 to August 2007. Histologic BE was diagnosed if salmon colored esophageal mucosa was endoscopically seen at least 1 cm above the top of the gastric folds and biopsy revealed intestinal metaplasia with Alcian blue-containing goblet cells. Demographic data collected for all included: age at diagnosis, ethnicity, sex, previous history of esophageal reflux, atypical manifestations (chronic cough, aspiration), endoscopic length of BE, presence or absence of hiatal hernia, esophageal stricture or ulcer, and presence or absence of dysplasia. Results: Salmon colored esophageal mucosa was observed in 405 of 7,308 patients (5.5%) and histologically confirmed in 115 of 405 patients (28%) reflecting an overall prevalence of BE of 115/7308 (1.6%) in this cohort. Ethnic distribution of histologic BE patients was as follows: 95 (83%) non-Hispanic white (nHw), 16 (14%) African American (AA) and 4 (3%) other. Long segment BE (LSBE) and any form of dysplasia was observed less frequently in AA than nHw (LSBE: 12% vs. 26% and dysplasia: 0% vs. 7%). Conclusions: LSBE and dysplasia are less frequent in AA than nHw. Studies in AA with BE may illustrate factors limiting dysplasia and LSBE risk.

AB - Background: Barrett's Esophagus (BE) is a pre-malignant condition. Limited data on BE dysplasia prevalence exists among United States ethnic groups. Aim: The purpose of this study was to determine if the frequency of BE with dysplasia varies among the major ethnic groups presenting to our institution. Methods: The University of Florida-Jacksonville endoscopy database was searched for all cases of endoscopic BE from September 2002 to August 2007. Histologic BE was diagnosed if salmon colored esophageal mucosa was endoscopically seen at least 1 cm above the top of the gastric folds and biopsy revealed intestinal metaplasia with Alcian blue-containing goblet cells. Demographic data collected for all included: age at diagnosis, ethnicity, sex, previous history of esophageal reflux, atypical manifestations (chronic cough, aspiration), endoscopic length of BE, presence or absence of hiatal hernia, esophageal stricture or ulcer, and presence or absence of dysplasia. Results: Salmon colored esophageal mucosa was observed in 405 of 7,308 patients (5.5%) and histologically confirmed in 115 of 405 patients (28%) reflecting an overall prevalence of BE of 115/7308 (1.6%) in this cohort. Ethnic distribution of histologic BE patients was as follows: 95 (83%) non-Hispanic white (nHw), 16 (14%) African American (AA) and 4 (3%) other. Long segment BE (LSBE) and any form of dysplasia was observed less frequently in AA than nHw (LSBE: 12% vs. 26% and dysplasia: 0% vs. 7%). Conclusions: LSBE and dysplasia are less frequent in AA than nHw. Studies in AA with BE may illustrate factors limiting dysplasia and LSBE risk.

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