Age-dependent rate of anaplastic transformation in low-grade astrocytoma

Saad Shafqat, E. Tessa Hedley-Whyte, John W. Henson

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Age and histologic grade are interrelated characteristics of diffuse fibrillary astrocytomas, because the peak age incidence rises with increasing grade. The relationship between age and grade may be explained if age determines the rate of anaplastic progression in astrocytomas. The authors tested this hypothesis by determining the interval between diagnosis of low- grade astrocytoma and progression to high-grade astrocytoma in patients of various ages. A two-way scatterplot of age at initial diagnosis versus interval to anaplastic progression demonstrated a strong negative correlation (n = 24; Pearson correlation coefficient = -0.83; Spearman correlation coefficient = -0.79; p < 0.001 for both values). It was concluded that the rate of anaplastic progression in low-grade astrocytoma is directly correlated with patient age.

Original languageEnglish (US)
Pages (from-to)867-869
Number of pages3
JournalNeurology
Volume52
Issue number4
DOIs
StatePublished - Mar 10 1999
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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