Age of onset, age at examination, and other covariates in the analysis of family data

R. C. Elston, V. T. George

Research output: Contribution to journalArticle

57 Scopus citations


Information on age of onset can easily be incorporated into regressive logistic models by assuming that age of onset follows a logistic distribution. This is analogous to previously proposed models based on the normal distribution. The two distributions, and hence the two types of models, are very similar. In each case the generalized modulus power transformation can be used as a basis for more flexibly modeling the age of onset distribution.

Original languageEnglish (US)
Pages (from-to)217-220
Number of pages4
JournalGenetic Epidemiology
Issue number1
StatePublished - 1989
Externally publishedYes



  • S.A.G.E.
  • affective disorder
  • regressive logistic models

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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