Aggression and schizophrenia: Efficacy of risperidone

Peter F. Buckley, Zafar Y. Ibrahim, Beth Singer, Bruce Orr, Karl Donenwirth, Parminder S. Brar

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The advent of novel antipsychotic medications has raised treatment expectations for patients with severe mental illness. In this regard, clozapine has been particularly effective in reducing aggressive behavior in patients with schizophrenia. This study compared the efficacy of risperidone and conventional antipsychotic medications in the management of hostile patients. Improvements in the level of aggression were evident over time in both treatment groups, and a similar response between risperidone and typical antipsychotics was observed. Future studies should address the relative role of typical antipsychotics, adjunctive agents, and novel antipsychotic medications in the pharmacological management of persistent aggression in patients with schizophrenia.

Original languageEnglish (US)
Pages (from-to)173-181
Number of pages9
JournalJournal of the American Academy of Psychiatry and the Law
Issue number2
StatePublished - 1997

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Psychiatry and Mental health


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