Aging, diabetes (DM), and hypertension are leading causes of cerebrovascular diseases (CVDs), contributing to stroke and cognitive impairments and CVD-related long-term disability and death. Emerging evidence suggests that mural cells on the cerebrovascular wall play an essential role in the regulation of cerebral vascular function. However, underlying mechanisms of how vascular smooth muscle cells (VSMCs) and pericytes interact with other cerebral vascular cells to modulate the autoregulation of cerebral blood flow (CBF) and maintain blood-brain barrier (BBB) integrity in aging and DM are just beginning to be understood.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Apr 15 2021|
- cerebral blood flow
- vascular smooth muscle cells
ASJC Scopus subject areas
- Cell Biology