Aging diabetes, deconstructing the cerebrovascular wall

Fan Fan; George W. Booz; Richard J. Roman

doi:10.18632/aging.202963

Aging diabetes, deconstructing the cerebrovascular wall

Fan Fan, George W. Booz, Richard J. Roman

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Aging, diabetes (DM), and hypertension are leading causes of cerebrovascular diseases (CVDs), contributing to stroke and cognitive impairments and CVD-related long-term disability and death. Emerging evidence suggests that mural cells on the cerebrovascular wall play an essential role in the regulation of cerebral vascular function. However, underlying mechanisms of how vascular smooth muscle cells (VSMCs) and pericytes interact with other cerebral vascular cells to modulate the autoregulation of cerebral blood flow (CBF) and maintain blood-brain barrier (BBB) integrity in aging and DM are just beginning to be understood.

Original language	English (US)
Pages (from-to)	9158-9159
Number of pages	2
Journal	Aging
Volume	13
Issue number	7
DOIs	https://doi.org/10.18632/aging.202963
State	Published - Apr 15 2021
Externally published	Yes

Keywords

aging
cerebral blood flow
hyperglycemia
pericytes
vascular smooth muscle cells

ASJC Scopus subject areas

Aging
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18632/aging.202963

Cite this

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abstract = "Aging, diabetes (DM), and hypertension are leading causes of cerebrovascular diseases (CVDs), contributing to stroke and cognitive impairments and CVD-related long-term disability and death. Emerging evidence suggests that mural cells on the cerebrovascular wall play an essential role in the regulation of cerebral vascular function. However, underlying mechanisms of how vascular smooth muscle cells (VSMCs) and pericytes interact with other cerebral vascular cells to modulate the autoregulation of cerebral blood flow (CBF) and maintain blood-brain barrier (BBB) integrity in aging and DM are just beginning to be understood.",

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AU - Fan, Fan

AU - Booz, George W.

AU - Roman, Richard J.

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PY - 2021/4/15

Y1 - 2021/4/15

N2 - Aging, diabetes (DM), and hypertension are leading causes of cerebrovascular diseases (CVDs), contributing to stroke and cognitive impairments and CVD-related long-term disability and death. Emerging evidence suggests that mural cells on the cerebrovascular wall play an essential role in the regulation of cerebral vascular function. However, underlying mechanisms of how vascular smooth muscle cells (VSMCs) and pericytes interact with other cerebral vascular cells to modulate the autoregulation of cerebral blood flow (CBF) and maintain blood-brain barrier (BBB) integrity in aging and DM are just beginning to be understood.

AB - Aging, diabetes (DM), and hypertension are leading causes of cerebrovascular diseases (CVDs), contributing to stroke and cognitive impairments and CVD-related long-term disability and death. Emerging evidence suggests that mural cells on the cerebrovascular wall play an essential role in the regulation of cerebral vascular function. However, underlying mechanisms of how vascular smooth muscle cells (VSMCs) and pericytes interact with other cerebral vascular cells to modulate the autoregulation of cerebral blood flow (CBF) and maintain blood-brain barrier (BBB) integrity in aging and DM are just beginning to be understood.

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Aging diabetes, deconstructing the cerebrovascular wall

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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