Aging, immunity and cancer

Claude Sportes, Frances T. Hakim

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Although the increased incidence of common cancers with age on one hand and immunosenescence on the other are both well documented in animal models and in humans, evidence for a causal link between the two is controversial. It is, therefore, most appropriate to critically consider whether the dysfunctional immune processes occurring with aging may play a contributing role in the increased incidence of cancer with aging. Indeed whether or not immunosenescence plays a significant role could have a determinant impact on devising cancer prevention and/or immunotherapeutic strategies for the presently growing elderly population.

Original languageEnglish (US)
Title of host publicationHandbook on Immunosenescence
Subtitle of host publicationBasic Understanding and Clinical Applications
PublisherSpringer Netherlands
Pages1119-1138
Number of pages20
ISBN (Electronic)9781402090639
ISBN (Print)9781402090622
DOIs
StatePublished - Jan 1 2009

Keywords

  • Adoptive immunotherapy
  • Immuno-editing
  • Immuno-surveillance
  • Inflammation
  • Primary immuno-deficiency

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Sportes, C., & Hakim, F. T. (2009). Aging, immunity and cancer. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (pp. 1119-1138). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9-55