Airborne tire particles in the environment: A possible asthma risk from latex proteins?

Brent L. Finley, Dennis R. Ownby, Sean M. Hays

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

A marked increase in asthma incidence has been reported worldwide over the past 10 years, particularly among children. Some authors have postulated that the increase could be related to the presence of natural rubber latex (NRL) proteins in airborne, respirable tire-wear particles. We reviewed the scientific literature to assess the plausibility of this hypothesis. Specifically, we reviewed the literature to determine the measured levels of tire particles in air, the bioavailability of the NRL antigenic proteins in tire particles, and whether the airborne levels of bioavailable NRL proteins might be sufficient to elicit asthma in a previously sensitized individual. Combining reported concentrations of ambient-air tire particles with the levels of extractable NRL antigens in tire particles yields a conservative estimate of approximately 0.004 ng bioavailable NRL antigen/m3 of ambient air. In a controlled exposure in which latex-sensitive patients were exposed to latex antigens from NRL gloves, a No-Adverse-Effect Level was found to be at airborne allergen levels ranging from 55 to 100 ng/m3. Hence, the current weight of evidence does not support the hypothesis that NRL in tire particulates is a significant contributor to asthma.

Original languageEnglish (US)
Pages (from-to)1505-1518
Number of pages14
JournalHuman and Ecological Risk Assessment
Volume9
Issue number6
DOIs
StatePublished - Oct 1 2003

Fingerprint

asthma
Latex
tire
Latexes
rubber
Tires
Rubber
Asthma
Proteins
protein
antigen
Particles (particulate matter)
Antigens
ambient air
Air
Allergens
Literature
particle
bioavailability
Biological Availability

Keywords

  • Airborne particulates
  • Asthma
  • Latex
  • Tire

ASJC Scopus subject areas

  • Ecological Modeling
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Airborne tire particles in the environment : A possible asthma risk from latex proteins? / Finley, Brent L.; Ownby, Dennis R.; Hays, Sean M.

In: Human and Ecological Risk Assessment, Vol. 9, No. 6, 01.10.2003, p. 1505-1518.

Research output: Contribution to journalReview article

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