Aktuelle Aspekte zum Management des Normaldruckglaukoms

Translated title of the contribution: Current aspects on the management of normal tension glaucoma

M. Töteberg-Harms, A. Rosentreter, A. Lappas, J. Funk, T. S. Dietlein

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


In a considerable proportion of glaucoma patients (25–50 %) the intraocular pressure (IOP) is not elevated higher than 22 mmHg at first diagnosis and during subsequent follow-up controls. Although the IOP level remains in the low range < 22 mmHg, progression of glaucoma can still occur. A multitude of different factors are assumed to be involved in glaucoma progression, such as very low nocturnal diastolic blood pressure values, a low mean ocular perfusion pressure, extensive fluctuations in perfusion (e.g. in cases of vascular dysregulation), an increased vulnerability of the optic nerve support structures, an increased translaminar pressure gradient and various underlying systemic diseases. The most important evidence-based aspect of treatment in normal tension glaucoma is pharmaceutical or surgical reduction of the IOP by 30 % or more in comparison to the initial pressure level. Vascular and neuroprotective concepts of treatment for normal tension glaucoma have been strongly advocated and the object of experimental and clinical studies. As yet a clear clinical benefit has not been proven by large prospective randomized studies.

Translated title of the contributionCurrent aspects on the management of normal tension glaucoma
Original languageGerman
Pages (from-to)943-956
Number of pages14
Issue number11
StatePublished - Nov 1 2015
Externally publishedYes


  • Glaucoma surgery
  • Intraocular pressure
  • Ocular perfusion
  • Risk factors
  • Therapy

ASJC Scopus subject areas

  • Ophthalmology


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