Allergic sensitization frequency and wheezing differences in early life between black and white children

Ganesa Wegienka, Suzanne Havstad, Christine L.M. Joseph, Edward Zoratti, Dennis Randall Ownby, Christine Cole Johnson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Asthma is more common in black children than in white children. Allergic sensitization has been shown to be associated with increased likelihood of asthma. This study was designed to determine whether there are racial differences in the allergens to which children are sensitized in the Detroit metropolitan area and determine whether sensitization was associated with wheeze outcomes. Pregnant women were recruited for the Wayne County Health, Environment, Allergy, and Asthma Longitudinal Study birth cohort to follow the health of their children in the Detroit metropolitan area. Specific IgE (sIgE) was measured for Alternaria, cat, cockroach, dog, Dermatophagoides farinae, short ragweed, timothy grass, egg, milk, and peanut in blood samples from the children at age 2 years. A positive allergen sIgE was defined as ≥0.35 IU/mL. Mothers reported their child's race and completed interviews at age 2 years about characteristics of wheezing episodes in their child (frequency, medication, acute care, or emergency department visit). Black children (n = 384) were more likely than white children (n = 180) to have been positive for each of the allergens tested and also tended to have positive responses to a greater number of allergens (four or more allergens: 9.2% versus 3.5%). Children who had two or more positive sIgEs (adjusted odds ratio [aOR] = 2.68; 95% 95% confidence interval [CI], 1.33, 5.46) or three or more positive sIgEs (aOR = 2.67, 95% CI, 1.19, 6.01) were more likely to have wheezed four or more times in the last 12 months. Racial differences in sensitization at this young age may contribute to the racial difference in asthma prevalence at later ages.

Original languageEnglish (US)
Pages (from-to)493-499
Number of pages7
JournalAllergy and Asthma Proceedings
Volume33
Issue number6
DOIs
StatePublished - Nov 1 2012

Fingerprint

Respiratory Sounds
Allergens
Asthma
Immunoglobulin E
Odds Ratio
Phleum
Dermatophagoides farinae
Confidence Intervals
Ambrosia
hydroquinone
Alternaria
Cockroaches
Ovum
Longitudinal Studies
Hospital Emergency Service
Pregnant Women
Hypersensitivity
Milk
Cats
Mothers

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Allergic sensitization frequency and wheezing differences in early life between black and white children. / Wegienka, Ganesa; Havstad, Suzanne; Joseph, Christine L.M.; Zoratti, Edward; Ownby, Dennis Randall; Johnson, Christine Cole.

In: Allergy and Asthma Proceedings, Vol. 33, No. 6, 01.11.2012, p. 493-499.

Research output: Contribution to journalArticle

Wegienka, Ganesa ; Havstad, Suzanne ; Joseph, Christine L.M. ; Zoratti, Edward ; Ownby, Dennis Randall ; Johnson, Christine Cole. / Allergic sensitization frequency and wheezing differences in early life between black and white children. In: Allergy and Asthma Proceedings. 2012 ; Vol. 33, No. 6. pp. 493-499.
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