TY - JOUR
T1 - Allogeneic stem cell transplantation for patients harboring T315I BCR-ABL mutated leukemias
AU - Nicolini, Franck Emmanuel
AU - Basak, Grzegorz W.
AU - Soverini, Simona
AU - Martinelli, Giovanni
AU - Mauro, Michael J.
AU - Müller, Martin C.
AU - Hochhaus, Andreas
AU - Chuah, Charles
AU - Dufva, Inge H.
AU - Rege-Cambrin, Giovanna
AU - Saglio, Giuseppe
AU - Michallet, Mauricette
AU - Labussière, Hélène
AU - Morisset, Stéphane
AU - Hayette, Sandrine
AU - Etienne, Gabriel
AU - Olavarria, Eduardo
AU - Zhou, Wei
AU - Peter, Senaka
AU - Apperley, Jane F.
AU - Cortes, Jorge
PY - 2011/11/17
Y1 - 2011/11/17
N2 - T315I+ Philadelphia chromosome-positive leukemias are inherently resistant to all licensed tyrosine kinase inhibitors, and therapeutic options remain limited.We report the outcome of allogeneic stem cell transplantation in 64 patients with documented BCR-ABLT315I mutations. Median follow-up was 52 months from mutation detection and 26 months from transplantation. At transplantation, 51.5% of patients with chronic myeloid leukemia were in the chronic phase and 4.5% were in advanced phases. Median overall survival after transplantation was 10.3 months (range 5.7 months to not reached [ie, still alive]) for those with chronic myeloid leukemia in the blast phase and 7.4 months (range 1.4 months to not reached [ie, still alive]) for those with Philadelphia chromosome-positive acute lymphoblastic leukemia but has not yet been reached for those in the chronic and accelerated phases of chronic myeloid leukemia. The occurrence of chronic GVHD had a positive impact on overall survival (P ∇ .047). Transplant-related mortality rates were low. Multivariate analysis identified only blast phase at transplantation (hazard ratio 3.68, P ∇ .0011) and unrelated stem cell donor (hazard ratio 2.98, P ∇ .011) as unfavorable factors. We conclude that allogeneic stem cell transplantation represents a valuable therapeutic tool for eligible patients with BCR-ABLT315I mutation, a tool that may or may not be replaced by third-generation tyrosine kinase inhibitors.
AB - T315I+ Philadelphia chromosome-positive leukemias are inherently resistant to all licensed tyrosine kinase inhibitors, and therapeutic options remain limited.We report the outcome of allogeneic stem cell transplantation in 64 patients with documented BCR-ABLT315I mutations. Median follow-up was 52 months from mutation detection and 26 months from transplantation. At transplantation, 51.5% of patients with chronic myeloid leukemia were in the chronic phase and 4.5% were in advanced phases. Median overall survival after transplantation was 10.3 months (range 5.7 months to not reached [ie, still alive]) for those with chronic myeloid leukemia in the blast phase and 7.4 months (range 1.4 months to not reached [ie, still alive]) for those with Philadelphia chromosome-positive acute lymphoblastic leukemia but has not yet been reached for those in the chronic and accelerated phases of chronic myeloid leukemia. The occurrence of chronic GVHD had a positive impact on overall survival (P ∇ .047). Transplant-related mortality rates were low. Multivariate analysis identified only blast phase at transplantation (hazard ratio 3.68, P ∇ .0011) and unrelated stem cell donor (hazard ratio 2.98, P ∇ .011) as unfavorable factors. We conclude that allogeneic stem cell transplantation represents a valuable therapeutic tool for eligible patients with BCR-ABLT315I mutation, a tool that may or may not be replaced by third-generation tyrosine kinase inhibitors.
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U2 - 10.1182/blood-2011-07-367326
DO - 10.1182/blood-2011-07-367326
M3 - Article
C2 - 21926354
AN - SCOPUS:80755185510
SN - 0006-4971
VL - 118
SP - 5697
EP - 5700
JO - Blood
JF - Blood
IS - 20
ER -