Denovo synthesis of alpha1-antitrypsin (α1AT) by human peripheral lymphocytes has been demonstrated in the present study. Treatment of the mononuclear cells with concanavalin A(Con A) resulted in a triple increase in the amount of α1AT synthesized by the untreated cells. A small amount of α1AT, equivalent to that synthesized by the unstimulated mononuclear cells, was observed in cultures of monocyte-depleted lymphocytes, with or without Con A stimulation. Monocytes treated with or without Con A scarcely synthesized α1AT. Conditioned media derived from monocyte enriched mononuclear cells treated with Con A enhanced about threefold α1AT synthesis by the Con A-stimulated lymphocytes. α1AT is suggested to be synthesized by lymphocytes assisted by monocytes.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Feb 26 1982|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology