Alpha1-antitrypsin synthesis by human lymphocytes

Tohru Ikuta, Hideo Okubo, Jiro Kudo, Hiromi Ishibashi, Takatoshi Inoue

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Denovo synthesis of alpha1-antitrypsin (α1AT) by human peripheral lymphocytes has been demonstrated in the present study. Treatment of the mononuclear cells with concanavalin A(Con A) resulted in a triple increase in the amount of α1AT synthesized by the untreated cells. A small amount of α1AT, equivalent to that synthesized by the unstimulated mononuclear cells, was observed in cultures of monocyte-depleted lymphocytes, with or without Con A stimulation. Monocytes treated with or without Con A scarcely synthesized α1AT. Conditioned media derived from monocyte enriched mononuclear cells treated with Con A enhanced about threefold α1AT synthesis by the Con A-stimulated lymphocytes. α1AT is suggested to be synthesized by lymphocytes assisted by monocytes.

Original languageEnglish (US)
Pages (from-to)1509-1516
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume104
Issue number4
DOIs
StatePublished - Feb 26 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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