ALSUntangled #68: ozone therapy

Yuyao Sun; Paul Barkhaus; Benjamin Barnes; Morgan Beauchamp; Michael Benatar; Tulio Bertorini; Mark Bromberg; Gregory T. Carter; Jesse Crayle; Merit Cudkowicz; Mazen Dimachkie; Eva L. Feldman; Timothy Fullam; Terry Heiman-Patterson; Sartaj Jhooty; Isaac Lund; Christopher Mcdermott; Gary Pattee; Kaitlyn Pierce; Dylan Ratner; Paul Wicks; Richard Bedlack

doi:10.1080/21678421.2022.2145904

ALSUntangled #68: ozone therapy

Yuyao Sun, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. Feldman, Timothy Fullam, Terry Heiman-Patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan RatnerPaul Wicks, Richard Bedlack

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review ozone therapy. Ozone therapy has possible mechanisms for slowing ALS progression based on its antioxidant, anti-inflammatory, and mitochondrial effects. A non-peer-reviewed report suggests that ozone treatment may slow progression in a mTDP-43 mouse model of ALS. One verified “ALS reversal” occurred on a cocktail of alternative treatments including ozone. There are no ALS trials using ozone to treat PALS. There can be potentially serious side effects associated with ozone therapy, depending on the dose. Based on the above information, we support an investigation of ozone therapy in ALS cell or animal models but cannot yet recommend it as a treatment in PALS.

Original language	English (US)
Pages (from-to)	548-552
Number of pages	5
Journal	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume	24
Issue number	5-6
DOIs	https://doi.org/10.1080/21678421.2022.2145904
State	Published - 2023

Keywords

ALS
alternative therapy
neurodegeneration
oxidative stress
ozone therapy

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1080/21678421.2022.2145904

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Sun, Y., Barkhaus, P., Barnes, B., Beauchamp, M., Benatar, M., Bertorini, T., Bromberg, M., Carter, G. T., Crayle, J., Cudkowicz, M., Dimachkie, M., Feldman, E. L., Fullam, T., Heiman-Patterson, T., Jhooty, S., Lund, I., Mcdermott, C., Pattee, G., Pierce, K., ... Bedlack, R. (2023). ALSUntangled #68: ozone therapy. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 24(5-6), 548-552. https://doi.org/10.1080/21678421.2022.2145904

Sun, Y, Barkhaus, P, Barnes, B, Beauchamp, M, Benatar, M, Bertorini, T, Bromberg, M, Carter, GT, Crayle, J, Cudkowicz, M, Dimachkie, M, Feldman, EL, Fullam, T, Heiman-Patterson, T, Jhooty, S, Lund, I, Mcdermott, C, Pattee, G, Pierce, K, Ratner, D, Wicks, P & Bedlack, R 2023, 'ALSUntangled #68: ozone therapy', Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, vol. 24, no. 5-6, pp. 548-552. https://doi.org/10.1080/21678421.2022.2145904

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abstract = "ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review ozone therapy. Ozone therapy has possible mechanisms for slowing ALS progression based on its antioxidant, anti-inflammatory, and mitochondrial effects. A non-peer-reviewed report suggests that ozone treatment may slow progression in a mTDP-43 mouse model of ALS. One verified “ALS reversal” occurred on a cocktail of alternative treatments including ozone. There are no ALS trials using ozone to treat PALS. There can be potentially serious side effects associated with ozone therapy, depending on the dose. Based on the above information, we support an investigation of ozone therapy in ALS cell or animal models but cannot yet recommend it as a treatment in PALS.",

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note = "Publisher Copyright: {\textcopyright} 2022 World Federation of Neurology on behalf of the Research Group on Motor Neuron Diseases.",

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doi = "10.1080/21678421.2022.2145904",

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AU - Sun, Yuyao

AU - Barkhaus, Paul

AU - Barnes, Benjamin

AU - Beauchamp, Morgan

AU - Benatar, Michael

AU - Bertorini, Tulio

AU - Bromberg, Mark

AU - Carter, Gregory T.

AU - Crayle, Jesse

AU - Cudkowicz, Merit

AU - Dimachkie, Mazen

AU - Feldman, Eva L.

AU - Fullam, Timothy

AU - Heiman-Patterson, Terry

AU - Jhooty, Sartaj

AU - Lund, Isaac

AU - Mcdermott, Christopher

AU - Pattee, Gary

AU - Pierce, Kaitlyn

AU - Ratner, Dylan

AU - Wicks, Paul

AU - Bedlack, Richard

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ALSUntangled #68: ozone therapy

Abstract

Keywords

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