TY - JOUR
T1 - Alterations in central hemodynamic in patients with COPD after acute high intensity exercise
AU - Behnia, M.
AU - Wheatley-Guy, C. M.
AU - Johnson, B. D.
AU - Avolio, A.
AU - Kim, C. H.
N1 - Publisher Copyright:
© 2020 Sociedade Portuguesa de Pneumologia
PY - 2021/5/1
Y1 - 2021/5/1
N2 - The present study investigated the relationship between central hemodynamics and lung function and the response to an acute bout of exercise in COPD. Methods: Based on the severity of COPD, moderate group (MOD, n = 12) and more mild group (MLD, n = 12) underwent central hemodynamic assessments pre- and post-peak exercise. Results: In the entire cohort (n = 24), central diastolic blood pressure (cDBP) was associated with pulmonary function. Post-exercise, cDBP remained elevated (p < 0.01), however, peripheral diastolic blood pressure (pDBP) was reduced (p = 0.02). Prior to exercise, the MOD showed higher cDBP and heart rate (HR) than the MLD (p = 0.02 and p = 0.01, respectively), but no difference in central aortic/arterial stiffness (p > 0.05). These findings remained similar post-exercise. Conclusion: Central diastolic blood pressure is linked to pulmonary function in COPD and it is elevated after exercise-induced reductions in pDBP. Central diastolic blood pressure is higher in the MOD than the MLD, however, there was no difference in central aortic/arterial stiffness between groups.
AB - The present study investigated the relationship between central hemodynamics and lung function and the response to an acute bout of exercise in COPD. Methods: Based on the severity of COPD, moderate group (MOD, n = 12) and more mild group (MLD, n = 12) underwent central hemodynamic assessments pre- and post-peak exercise. Results: In the entire cohort (n = 24), central diastolic blood pressure (cDBP) was associated with pulmonary function. Post-exercise, cDBP remained elevated (p < 0.01), however, peripheral diastolic blood pressure (pDBP) was reduced (p = 0.02). Prior to exercise, the MOD showed higher cDBP and heart rate (HR) than the MLD (p = 0.02 and p = 0.01, respectively), but no difference in central aortic/arterial stiffness (p > 0.05). These findings remained similar post-exercise. Conclusion: Central diastolic blood pressure is linked to pulmonary function in COPD and it is elevated after exercise-induced reductions in pDBP. Central diastolic blood pressure is higher in the MOD than the MLD, however, there was no difference in central aortic/arterial stiffness between groups.
KW - COPD
KW - Central aortic pressure
KW - Lung function
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U2 - 10.1016/j.pulmoe.2020.06.006
DO - 10.1016/j.pulmoe.2020.06.006
M3 - Article
C2 - 32622734
AN - SCOPUS:85087356503
SN - 2531-0429
VL - 27
SP - 215
EP - 218
JO - Pulmonology
JF - Pulmonology
IS - 3
ER -