Alveolar ridge and maxillary sinus augmentation using rhBMP-2

a systematic review

Rubens Moreno de Freitas, Rubens Spin-Neto, Elcio Marcantonio Junior, Luís Antônio Violin Dias Pereira, Ulf M E Wikesjö, Cristiano Susin

Research output: Contribution to journalReview article

Abstract

PURPOSE: The aim of this systematic review was to evaluate clinical and safety data for recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier when used for alveolar ridge/maxillary sinus augmentation in humans.

MATERIALS AND METHODS: Clinical studies/case series published 1980 through June 2012 using rhBMP-2/ACS were searched. Studies meeting the following criteria were considered eligible for inclusion: >10 subjects at baseline and maxillary sinus or alveolar ridge augmentation not concomitant with implant placement.

RESULTS: Seven of 69 publications were eligible for review. rhBMP-2/ACS yielded clinically meaningful bone formation for maxillary sinus augmentation that would allow placement of regular dental implants without consistent differences between rhBMP-2 concentrations. Nevertheless, the statistical analysis showed that sinus augmentation following autogenous bone graft was significantly greater (mean bone height: 1.6 mm, 95% CI: 0.5-2.7 mm) than for rhBMP-2/ACS (rhBMP-2 at 1.5 mg/mL). In extraction sockets, rhBMP-2/ACS maintained alveolar ridge height while enhancing alveolar ridge width. Safety reports did not represent concerns for the proposed indications.

CONCLUSIONS: rhBMP-2/ACS appears a promising alternative to autogenous bone grafts for alveolar ridge/maxillary sinus augmentation; dose and carrier optimization may expand its efficacy, use, and clinical application.

Original languageEnglish (US)
Pages (from-to)e192-e201
JournalClinical Implant Dentistry and Related Research
Volume17
DOIs
StatePublished - Jan 1 2015

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Alveolar Process
Maxillary Sinus
Porifera
Collagen
Alveolar Ridge Augmentation
Bone and Bones
Transplants
Safety
Dental Implants
recombinant human bone morphogenetic protein-2
Osteogenesis
Publications

Keywords

  • BMP
  • alveolar ridge augmentation
  • bone morphogenetic proteins
  • bone regeneration
  • maxillary sinus augmentation

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry(all)

Cite this

Freitas, R. M. D., Spin-Neto, R., Marcantonio Junior, E., Pereira, L. A. V. D., Wikesjö, U. M. E., & Susin, C. (2015). Alveolar ridge and maxillary sinus augmentation using rhBMP-2: a systematic review. Clinical Implant Dentistry and Related Research, 17, e192-e201. https://doi.org/10.1111/cid.12156

Alveolar ridge and maxillary sinus augmentation using rhBMP-2 : a systematic review. / Freitas, Rubens Moreno de; Spin-Neto, Rubens; Marcantonio Junior, Elcio; Pereira, Luís Antônio Violin Dias; Wikesjö, Ulf M E; Susin, Cristiano.

In: Clinical Implant Dentistry and Related Research, Vol. 17, 01.01.2015, p. e192-e201.

Research output: Contribution to journalReview article

Freitas, RMD, Spin-Neto, R, Marcantonio Junior, E, Pereira, LAVD, Wikesjö, UME & Susin, C 2015, 'Alveolar ridge and maxillary sinus augmentation using rhBMP-2: a systematic review', Clinical Implant Dentistry and Related Research, vol. 17, pp. e192-e201. https://doi.org/10.1111/cid.12156
Freitas RMD, Spin-Neto R, Marcantonio Junior E, Pereira LAVD, Wikesjö UME, Susin C. Alveolar ridge and maxillary sinus augmentation using rhBMP-2: a systematic review. Clinical Implant Dentistry and Related Research. 2015 Jan 1;17:e192-e201. https://doi.org/10.1111/cid.12156
Freitas, Rubens Moreno de ; Spin-Neto, Rubens ; Marcantonio Junior, Elcio ; Pereira, Luís Antônio Violin Dias ; Wikesjö, Ulf M E ; Susin, Cristiano. / Alveolar ridge and maxillary sinus augmentation using rhBMP-2 : a systematic review. In: Clinical Implant Dentistry and Related Research. 2015 ; Vol. 17. pp. e192-e201.
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