Alveolar ridge and maxillary sinus augmentation using rhBMP-2: a systematic review

Rubens Moreno de Freitas, Rubens Spin-Neto, Elcio Marcantonio Junior, Luís Antônio Violin Dias Pereira, Ulf M E Wikesjö, Cristiano Susin

Research output: Contribution to journalReview articlepeer-review


PURPOSE: The aim of this systematic review was to evaluate clinical and safety data for recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier when used for alveolar ridge/maxillary sinus augmentation in humans.

MATERIALS AND METHODS: Clinical studies/case series published 1980 through June 2012 using rhBMP-2/ACS were searched. Studies meeting the following criteria were considered eligible for inclusion: >10 subjects at baseline and maxillary sinus or alveolar ridge augmentation not concomitant with implant placement.

RESULTS: Seven of 69 publications were eligible for review. rhBMP-2/ACS yielded clinically meaningful bone formation for maxillary sinus augmentation that would allow placement of regular dental implants without consistent differences between rhBMP-2 concentrations. Nevertheless, the statistical analysis showed that sinus augmentation following autogenous bone graft was significantly greater (mean bone height: 1.6 mm, 95% CI: 0.5-2.7 mm) than for rhBMP-2/ACS (rhBMP-2 at 1.5 mg/mL). In extraction sockets, rhBMP-2/ACS maintained alveolar ridge height while enhancing alveolar ridge width. Safety reports did not represent concerns for the proposed indications.

CONCLUSIONS: rhBMP-2/ACS appears a promising alternative to autogenous bone grafts for alveolar ridge/maxillary sinus augmentation; dose and carrier optimization may expand its efficacy, use, and clinical application.

Original languageEnglish (US)
Pages (from-to)e192-e201
JournalClinical Implant Dentistry and Related Research
StatePublished - Jan 1 2015


  • BMP
  • alveolar ridge augmentation
  • bone morphogenetic proteins
  • bone regeneration
  • maxillary sinus augmentation

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry(all)


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