Ambient manganese exposure is negatively associated with human sperm motility and concentration

Julia J. Wirth, Mary G. Rossano, Douglas C. Daly, Nigel Paneth, Elizabeth Puscheck, Rachel C. Potter, Michael Peter Diamond

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

BACKGROUND: Occupational and experimental animal studies indicate that exposure to high levels of manganese impairs male fertility, but the effects of ambient manganese in humans are not known. METHODS: We measured blood levels of manganese and selenium in 200 infertility clinic clients in a cross-sectional study. Correlations between metals and semen variables were determined, adjusting for other risk factors. Outcomes were low motility (<50% motile), low concentration (<20 million/mL), or low morphology (<4% normal). We also investigated dose-response relationships between quartiles of manganese exposure and sperm parameters. RESULTS: High manganese level was associated with increased risk of low sperm motility (odds ratio = 5.4; 95% confidence interval = 1.6-17.6) and low sperm concentration (2.4; 1.2-4.9). We saw a U-shaped dose-response pattern between quartiles of manganese exposure and all 3 sperm parameters. CONCLUSION: Ambient exposure to manganese levels is associated with a reduction in sperm motility and concentration. No adverse effects were seen for high selenium.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalEpidemiology
Volume18
Issue number2
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

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Sperm Motility
Manganese
Spermatozoa
Selenium
Fertility Agents
Semen
Infertility
Cross-Sectional Studies
Metals
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Epidemiology

Cite this

Ambient manganese exposure is negatively associated with human sperm motility and concentration. / Wirth, Julia J.; Rossano, Mary G.; Daly, Douglas C.; Paneth, Nigel; Puscheck, Elizabeth; Potter, Rachel C.; Diamond, Michael Peter.

In: Epidemiology, Vol. 18, No. 2, 01.03.2007, p. 270-273.

Research output: Contribution to journalArticle

Wirth, Julia J. ; Rossano, Mary G. ; Daly, Douglas C. ; Paneth, Nigel ; Puscheck, Elizabeth ; Potter, Rachel C. ; Diamond, Michael Peter. / Ambient manganese exposure is negatively associated with human sperm motility and concentration. In: Epidemiology. 2007 ; Vol. 18, No. 2. pp. 270-273.
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AU - Potter, Rachel C.

AU - Diamond, Michael Peter

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