Ambient manganese exposure is negatively associated with human sperm motility and concentration

Julia J. Wirth, Mary G. Rossano, Douglas C. Daly, Nigel Paneth, Elizabeth Puscheck, Rachel C. Potter, Michael P. Diamond

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

BACKGROUND: Occupational and experimental animal studies indicate that exposure to high levels of manganese impairs male fertility, but the effects of ambient manganese in humans are not known. METHODS: We measured blood levels of manganese and selenium in 200 infertility clinic clients in a cross-sectional study. Correlations between metals and semen variables were determined, adjusting for other risk factors. Outcomes were low motility (<50% motile), low concentration (<20 million/mL), or low morphology (<4% normal). We also investigated dose-response relationships between quartiles of manganese exposure and sperm parameters. RESULTS: High manganese level was associated with increased risk of low sperm motility (odds ratio = 5.4; 95% confidence interval = 1.6-17.6) and low sperm concentration (2.4; 1.2-4.9). We saw a U-shaped dose-response pattern between quartiles of manganese exposure and all 3 sperm parameters. CONCLUSION: Ambient exposure to manganese levels is associated with a reduction in sperm motility and concentration. No adverse effects were seen for high selenium.

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalEpidemiology
Volume18
Issue number2
DOIs
Publication statusPublished - Mar 1 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Epidemiology

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