Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. linn leaf extracts

Mahendra Jain, Rakhee Kapadia, Ravirajsinh N. Jadeja, Menaka C. Thounaojam, Ranjitsinh V. Devkar, S. H. Mishra

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl 4) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl 4 recorded significant elevation in plasma markers of hepatic injury, alteration in hepatic antioxidant status and histopathological damages. However, rats pretreated with FL-7 (200 or 400 mg/kg, p.o.) and FL-9 (100 or 200 mg/kg, p.o.) for 7 days and later administered CCl 4 (0.5 ml/kg, i.p.) recorded lowered indices of the above mentioned parameters and minimal histological damage in a dose dependent manner. These results were comparable to that of CCl 4+silymarin treated rats. The results obtained with FL-7 and FL-9 are attributable to their free radical scavenging potential due to high contents of polyphenols and flavonols recorded herein. Overall, this study establishes the efficacy of FL-7 and FL-9 as hepatoprotective agents against CCl 4 induced hepatotoxicity in rats.

Original languageEnglish (US)
Pages (from-to)250-259
Number of pages10
JournalEXCLI Journal
Volume11
StatePublished - Oct 23 2012

Keywords

  • Carbon tetrachloride
  • Feronia limonia
  • Histopathology
  • Silymarin

ASJC Scopus subject areas

  • Molecular Medicine
  • Animal Science and Zoology
  • Pharmacology
  • Drug Discovery

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