Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. linn leaf extracts

Mahendra Jain, Rakhee Kapadia, Ravirajsinh N. Jadeja, Menaka Thounaojam, Ranjitsinh V. Devkar, S. H. Mishra

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl 4) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl 4 recorded significant elevation in plasma markers of hepatic injury, alteration in hepatic antioxidant status and histopathological damages. However, rats pretreated with FL-7 (200 or 400 mg/kg, p.o.) and FL-9 (100 or 200 mg/kg, p.o.) for 7 days and later administered CCl 4 (0.5 ml/kg, i.p.) recorded lowered indices of the above mentioned parameters and minimal histological damage in a dose dependent manner. These results were comparable to that of CCl 4+silymarin treated rats. The results obtained with FL-7 and FL-9 are attributable to their free radical scavenging potential due to high contents of polyphenols and flavonols recorded herein. Overall, this study establishes the efficacy of FL-7 and FL-9 as hepatoprotective agents against CCl 4 induced hepatotoxicity in rats.

Original languageEnglish (US)
Pages (from-to)250-259
Number of pages10
JournalEXCLI Journal
Volume11
StatePublished - Oct 23 2012
Externally publishedYes

Fingerprint

Limonia acidissima
Plumbaginaceae
carbon tetrachloride
hepatotoxicity
Carbon Tetrachloride
leaf extracts
rats
Rutaceae
Silymarin
silymarin
Flavonols
liver
Liver
Polyphenols
Chloroform
flavonols
chloroform
Free Radicals
polyphenols
Oxidative Stress

Keywords

  • Carbon tetrachloride
  • Feronia limonia
  • Histopathology
  • Silymarin

ASJC Scopus subject areas

  • Molecular Medicine
  • Animal Science and Zoology
  • Pharmacology
  • Drug Discovery

Cite this

Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. linn leaf extracts. / Jain, Mahendra; Kapadia, Rakhee; Jadeja, Ravirajsinh N.; Thounaojam, Menaka; Devkar, Ranjitsinh V.; Mishra, S. H.

In: EXCLI Journal, Vol. 11, 23.10.2012, p. 250-259.

Research output: Contribution to journalArticle

Jain, Mahendra ; Kapadia, Rakhee ; Jadeja, Ravirajsinh N. ; Thounaojam, Menaka ; Devkar, Ranjitsinh V. ; Mishra, S. H. / Amelioration of carbon tetrachloride induced hepatotoxicity in rats by standardized Feronia limonia. linn leaf extracts. In: EXCLI Journal. 2012 ; Vol. 11. pp. 250-259.
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