Abstract
The hepatoprotective potential of standardized Feronia limonia (Family, Rutaceae) methanolic extract (FL-7) and chloroform soluble fraction (FL-9) were assessed against carbon tetrachloride (CCl 4) induced oxidative stress and hepatotoxicity in rats. Rats treated with CCl 4 recorded significant elevation in plasma markers of hepatic injury, alteration in hepatic antioxidant status and histopathological damages. However, rats pretreated with FL-7 (200 or 400 mg/kg, p.o.) and FL-9 (100 or 200 mg/kg, p.o.) for 7 days and later administered CCl 4 (0.5 ml/kg, i.p.) recorded lowered indices of the above mentioned parameters and minimal histological damage in a dose dependent manner. These results were comparable to that of CCl 4+silymarin treated rats. The results obtained with FL-7 and FL-9 are attributable to their free radical scavenging potential due to high contents of polyphenols and flavonols recorded herein. Overall, this study establishes the efficacy of FL-7 and FL-9 as hepatoprotective agents against CCl 4 induced hepatotoxicity in rats.
Original language | English (US) |
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Pages (from-to) | 250-259 |
Number of pages | 10 |
Journal | EXCLI Journal |
Volume | 11 |
State | Published - Oct 23 2012 |
Externally published | Yes |
Keywords
- Carbon tetrachloride
- Feronia limonia
- Histopathology
- Silymarin
ASJC Scopus subject areas
- Molecular Medicine
- Animal Science and Zoology
- Pharmacology
- Drug Discovery