Amelioration of cognitive impairment and neurodegeneration by catechin hydrate in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

Fakhrul Islam, Md Ejaz Ahmed, Mohd Moshahid Khan, Hayate Javed, Kumar Vaibhav, Andleeb Khan, Rizwana Tabassum, Mohammad Ashafaq, Farah Islam, Mohammed M. Safhi

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder resulting in cognitive decline and enhancement of oxidative loads in the brain. Flavonoids have been considered to exert human health benefits by anti-oxidant and anti-inflammatory properties. The present study is aimed to elucidate the neuroprotective effect of catechin hydrate (CH), a natural flavanoid with potential antioxidant and anti-inflammatory properties, on intracerebroventricular streptozotocin (ICV-STZ) induced neuronal loss and memory impairment. To test this hypothesis, male Wistar rats were pretreated with CH (10 and 20 mg/kg bwt) orally once daily for 21 days and then bilaterally injected with ICV-STZ (3 mg/kg bwt), while sham group rats receive the same volume of vehicle. After 2 weeks of ICV-STZ infusion, rats were tested for cognitive performance using Morris water maze (MWM) test and then sacrifice for biochemical and histopathological assays. CH was found to be successful in upregulating the antioxidant status and prevented the memory loss. The expression of choline acetyl transferase (ChAT) was decreased in ICV-STZ group and CH pretreatment increases the expression of ChAT. Moreover, inflammatory mediators like TNF-α, IL-1β levels and expression of iNOS were significantly attenuated by CH pretreatment. The study suggests that CH is effective in preventing memory loss, ameliorating the oxidative stress and might be beneficial for the treatment of sporadic dementia of Alzheimer's type (SDAT).

Original languageEnglish (US)
Pages (from-to)492-501
Number of pages10
JournalNeurochemistry International
Volume62
Issue number4
DOIs
StatePublished - Mar 1 2013

Keywords

  • Catechin hydrate
  • Cognitive impairment
  • Oxidative stress
  • Streptozotocin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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