Aminoacyl benzotriazolides: Versatile reagents for the preparation of peptides and their mimetics and conjugates

Siva S. Panda, C. Dennis Hall, Eric Scriven, Alan R. Katritzky

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

N-(Protected α-aminoacyl)benzotriazoles are efficient acylating reagents that offer many advantages in the preparation of peptides and their mimetics and conjugates. Advances in methodology, made possible by these novel reagents, have given rise to solution- and solid-phase preparative techniques for generating complex peptides and peptide conjugates, which are useful in the construction of diverse libraries of building blocks for medicinal chemistry.

Original languageEnglish (US)
Pages (from-to)43-58
Number of pages16
JournalAldrichimica Acta
Volume46
Issue number2
StatePublished - 2013

Fingerprint

Peptides
Pharmaceutical Chemistry
benzotriazole

Keywords

  • Benzotriazole
  • Conjugates
  • Coupling reagent
  • Methodology
  • Peptide synthesis
  • Peptidomimetics

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Aminoacyl benzotriazolides : Versatile reagents for the preparation of peptides and their mimetics and conjugates. / Panda, Siva S.; Hall, C. Dennis; Scriven, Eric; Katritzky, Alan R.

In: Aldrichimica Acta, Vol. 46, No. 2, 2013, p. 43-58.

Research output: Contribution to journalArticle

Panda, Siva S. ; Hall, C. Dennis ; Scriven, Eric ; Katritzky, Alan R. / Aminoacyl benzotriazolides : Versatile reagents for the preparation of peptides and their mimetics and conjugates. In: Aldrichimica Acta. 2013 ; Vol. 46, No. 2. pp. 43-58.
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