Aminoisoquinolines as colorimetric Hg2+ sensors: the importance of molecular structure and sacrificial base

Yanjun Wan, Weijun Niu, William J. Behof, Yifei Wang, Paul Boyle, Christopher B. Gorman

Research output: Contribution to journalArticle

32 Scopus citations


Here it is shown that 3-phenyl-2-amino isoquinoline acts as a simple mercury sensor. It is simple to synthesize. The molecule requires base/buffer to bind in a 1:1 stoichiometry with mercury ion, however. Otherwise, it acts as a sacrificial base, presumably to pick up a proton liberated during binding. This binding is characterized quantitatively.

Original languageEnglish (US)
Pages (from-to)4293-4297
Number of pages5
Issue number22
StatePublished - May 30 2009


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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