Aminoisoquinolines as colorimetric Hg2+ sensors

the importance of molecular structure and sacrificial base

Yanjun Jean Wan, Weijun Niu, William J. Behof, Yifei Wang, Paul Boyle, Christopher B. Gorman

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Here it is shown that 3-phenyl-2-amino isoquinoline acts as a simple mercury sensor. It is simple to synthesize. The molecule requires base/buffer to bind in a 1:1 stoichiometry with mercury ion, however. Otherwise, it acts as a sacrificial base, presumably to pick up a proton liberated during binding. This binding is characterized quantitatively.

Original languageEnglish (US)
Pages (from-to)4293-4297
Number of pages5
JournalTetrahedron
Volume65
Issue number22
DOIs
StatePublished - May 30 2009

Fingerprint

Molecular Structure
Mercury
Molecular structure
Sensors
Stoichiometry
Protons
Buffers
Ions
Molecules
isoquinoline

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Aminoisoquinolines as colorimetric Hg2+ sensors : the importance of molecular structure and sacrificial base. / Wan, Yanjun Jean; Niu, Weijun; Behof, William J.; Wang, Yifei; Boyle, Paul; Gorman, Christopher B.

In: Tetrahedron, Vol. 65, No. 22, 30.05.2009, p. 4293-4297.

Research output: Contribution to journalArticle

Wan, Yanjun Jean ; Niu, Weijun ; Behof, William J. ; Wang, Yifei ; Boyle, Paul ; Gorman, Christopher B. / Aminoisoquinolines as colorimetric Hg2+ sensors : the importance of molecular structure and sacrificial base. In: Tetrahedron. 2009 ; Vol. 65, No. 22. pp. 4293-4297.
@article{71bb68bbca24477f93fe4bfc52c36aaa,
title = "Aminoisoquinolines as colorimetric Hg2+ sensors: the importance of molecular structure and sacrificial base",
abstract = "Here it is shown that 3-phenyl-2-amino isoquinoline acts as a simple mercury sensor. It is simple to synthesize. The molecule requires base/buffer to bind in a 1:1 stoichiometry with mercury ion, however. Otherwise, it acts as a sacrificial base, presumably to pick up a proton liberated during binding. This binding is characterized quantitatively.",
author = "Wan, {Yanjun Jean} and Weijun Niu and Behof, {William J.} and Yifei Wang and Paul Boyle and Gorman, {Christopher B.}",
year = "2009",
month = "5",
day = "30",
doi = "10.1016/j.tet.2009.03.063",
language = "English (US)",
volume = "65",
pages = "4293--4297",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "22",

}

TY - JOUR

T1 - Aminoisoquinolines as colorimetric Hg2+ sensors

T2 - the importance of molecular structure and sacrificial base

AU - Wan, Yanjun Jean

AU - Niu, Weijun

AU - Behof, William J.

AU - Wang, Yifei

AU - Boyle, Paul

AU - Gorman, Christopher B.

PY - 2009/5/30

Y1 - 2009/5/30

N2 - Here it is shown that 3-phenyl-2-amino isoquinoline acts as a simple mercury sensor. It is simple to synthesize. The molecule requires base/buffer to bind in a 1:1 stoichiometry with mercury ion, however. Otherwise, it acts as a sacrificial base, presumably to pick up a proton liberated during binding. This binding is characterized quantitatively.

AB - Here it is shown that 3-phenyl-2-amino isoquinoline acts as a simple mercury sensor. It is simple to synthesize. The molecule requires base/buffer to bind in a 1:1 stoichiometry with mercury ion, however. Otherwise, it acts as a sacrificial base, presumably to pick up a proton liberated during binding. This binding is characterized quantitatively.

UR - http://www.scopus.com/inward/record.url?scp=65249113812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249113812&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2009.03.063

DO - 10.1016/j.tet.2009.03.063

M3 - Article

VL - 65

SP - 4293

EP - 4297

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 22

ER -