Amnesia After Unilateral Temporal Lobectomy: A Case Report

David W. Loring; Bruce P. Hermann; Kimford J. Meador; Gregory P. Lee; Brian B. Gallagher; Don W. King; Anthony M. Murro; Joseph R. Smith; Allen R. Wyler

doi:10.1111/j.1528-1157.1994.tb02507.x

Amnesia After Unilateral Temporal Lobectomy: A Case Report

David W. Loring, Bruce P. Hermann, Kimford J. Meador, Gregory P. Lee, Brian B. Gallagher, Don W. King, Anthony M. Murro, Joseph R. Smith, Allen R. Wyler

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Summary: We report a mixed handed (L>R) patient with exclusive right cerebral language representation who de–veloped a permanent anterograde amnestic syndrome after right anterotemporal lobectomy. Preoperative neuropsychological performance consisted of impaired verbal memory and normal nonverbal memory. Wada memory performance was asymmetrical for objects presented soon after amobarbital injection in conjunction with no memory asymmetry for items presented later in the Wada evaluation. Preand postoperative magnetic resonance imaging (MRI) scans showed no structural lesions; however, postoperative MRI hippocampal volume measurements suggested decreased hippocampal volume for the nonresected temporal lobe. These results confirm the risk of anterograde amnesia after unilateral temporal lobectomy and demonstrate that baseline neuropsychological testing may falsely literalize material‐specific memory functions in patients with atypical cerebral language dominance.

Original language	English (US)
Pages (from-to)	757-763
Number of pages	7
Journal	Epilepsia
Volume	35
Issue number	4
DOIs	https://doi.org/10.1111/j.1528-1157.1994.tb02507.x
State	Published - Jul 1994
Externally published	Yes

Keywords

Amnesia
Epilepsy
Neurosurgery
Temporallobe
Wada test

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/j.1528-1157.1994.tb02507.x

Cite this

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title = "Amnesia After Unilateral Temporal Lobectomy: A Case Report",

abstract = "Summary: We report a mixed handed (L>R) patient with exclusive right cerebral language representation who de–veloped a permanent anterograde amnestic syndrome after right anterotemporal lobectomy. Preoperative neuropsychological performance consisted of impaired verbal memory and normal nonverbal memory. Wada memory performance was asymmetrical for objects presented soon after amobarbital injection in conjunction with no memory asymmetry for items presented later in the Wada evaluation. Preand postoperative magnetic resonance imaging (MRI) scans showed no structural lesions; however, postoperative MRI hippocampal volume measurements suggested decreased hippocampal volume for the nonresected temporal lobe. These results confirm the risk of anterograde amnesia after unilateral temporal lobectomy and demonstrate that baseline neuropsychological testing may falsely literalize material‐specific memory functions in patients with atypical cerebral language dominance.",

keywords = "Amnesia, Epilepsy, Neurosurgery, Temporallobe, Wada test",

author = "Loring, {David W.} and Hermann, {Bruce P.} and Meador, {Kimford J.} and Lee, {Gregory P.} and Gallagher, {Brian B.} and King, {Don W.} and Murro, {Anthony M.} and Smith, {Joseph R.} and Wyler, {Allen R.}",

year = "1994",

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language = "English (US)",

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T2 - A Case Report

AU - Loring, David W.

AU - Hermann, Bruce P.

AU - Meador, Kimford J.

AU - Lee, Gregory P.

AU - Gallagher, Brian B.

AU - King, Don W.

AU - Murro, Anthony M.

AU - Smith, Joseph R.

AU - Wyler, Allen R.

PY - 1994/7

Y1 - 1994/7

N2 - Summary: We report a mixed handed (L>R) patient with exclusive right cerebral language representation who de–veloped a permanent anterograde amnestic syndrome after right anterotemporal lobectomy. Preoperative neuropsychological performance consisted of impaired verbal memory and normal nonverbal memory. Wada memory performance was asymmetrical for objects presented soon after amobarbital injection in conjunction with no memory asymmetry for items presented later in the Wada evaluation. Preand postoperative magnetic resonance imaging (MRI) scans showed no structural lesions; however, postoperative MRI hippocampal volume measurements suggested decreased hippocampal volume for the nonresected temporal lobe. These results confirm the risk of anterograde amnesia after unilateral temporal lobectomy and demonstrate that baseline neuropsychological testing may falsely literalize material‐specific memory functions in patients with atypical cerebral language dominance.

AB - Summary: We report a mixed handed (L>R) patient with exclusive right cerebral language representation who de–veloped a permanent anterograde amnestic syndrome after right anterotemporal lobectomy. Preoperative neuropsychological performance consisted of impaired verbal memory and normal nonverbal memory. Wada memory performance was asymmetrical for objects presented soon after amobarbital injection in conjunction with no memory asymmetry for items presented later in the Wada evaluation. Preand postoperative magnetic resonance imaging (MRI) scans showed no structural lesions; however, postoperative MRI hippocampal volume measurements suggested decreased hippocampal volume for the nonresected temporal lobe. These results confirm the risk of anterograde amnesia after unilateral temporal lobectomy and demonstrate that baseline neuropsychological testing may falsely literalize material‐specific memory functions in patients with atypical cerebral language dominance.

KW - Amnesia

KW - Epilepsy

KW - Neurosurgery

KW - Temporallobe

KW - Wada test

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ER -

Amnesia After Unilateral Temporal Lobectomy: A Case Report

Abstract

Keywords

ASJC Scopus subject areas

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