Amobarbital dose effects on Wada memory testing

David W. Loring, Kimford J. Meador, Gregory P. Lee

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We investigated the relationship of amobarbital dosage to Wada memory performance in 72 patients who have subsequently undergone unilateral anterior temporal lobectomy (left, 39; right, 33). Significantly poorer recognition memory performance following injection ipsilateral to the seizure focus was associated with higher amobarbital dosage administration (r = -0.40; p <0.001). Patients were also dichotomized into "low" (125 mg and lower) and "high" (greater than 125 mg) dosage groups based on ipsilateral dosage, and significantly poorer recognition memory performance (p < 0.001) was observed following higher amobarbital administration. These data demonstrate that amobarbital dosage is one factor that contributes to memory performance during the Wada test.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalJournal of Epilepsy
Volume5
Issue number3
DOIs
StatePublished - 1992

Keywords

  • Amobarbital
  • Epilepsy
  • Memory
  • Temporal lobectomy
  • Wada test

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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