Amplification of rabies virus-induced stimulation of human T-cell lines and clones by antigen-specific antibodies

Esteban Celis, T. J. Wiktor, B. Dietzschold, H. Koprowski

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The effect of antigen-specific antibodies on the response of human T-cell lines and clones to rabies virus was studied. Plasmas from rabies-immune vaccine recipients, but not those from nonimmune individuals, enhanced the proliferative response of rabies-reactive T cells to whole inactivated virus or to the purified glycoprotein and nucleocapsid from the rabies virion. Rabies-immune plasma also increased the antigen-induced production of gamma interferon by the rabies-specific T-cell lines. Experiments performed on T-cell clones specific for either rabies glycoprotein or nucleocapsid showed that immune plasma as well as antiglycoprotein and antinucleoprotein murine monoclonal antibodies possessed the capacity to increase significantly the antigen-induced proliferative responses of these clones. The overall results indicate that this in vitro effect of antigen-specific antibodies on the response of regulatory T lymphocytes to rabies virus could be an important factor in the development of effective immune responses in vivo to rabies virus.

Original languageEnglish (US)
Pages (from-to)426-433
Number of pages8
JournalJournal of Virology
Volume56
Issue number2
StatePublished - Dec 1 1985
Externally publishedYes

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Rabies virus
Rabies
rabies
Clone Cells
T-lymphocytes
cell lines
clones
antigens
T-Lymphocytes
Antigens
Cell Line
antibodies
Antibodies
Nucleocapsid
nucleocapsid
Antibody Formation
Glycoproteins
glycoproteins
Rabies Vaccines
Regulatory T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

Cite this

Amplification of rabies virus-induced stimulation of human T-cell lines and clones by antigen-specific antibodies. / Celis, Esteban; Wiktor, T. J.; Dietzschold, B.; Koprowski, H.

In: Journal of Virology, Vol. 56, No. 2, 01.12.1985, p. 426-433.

Research output: Contribution to journalArticle

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