An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children

Cynthia E. Krafft, Nicolette F. Schwarz, Lingxi Chi, Abby L. Weinberger, David J. Schaeffer, Jordan E. Pierce, Amanda L. Rodrigue, Nathan Eugene Yanasak, Patricia H. Miller, Phillip D. Tomporowski, Catherine Lucy Davis, Jennifer E. McDowell

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objective Children who are less fit reportedly have lower performance on tests of cognitive control and differences in brain function. This study examined the effect of an exercise intervention on brain function during two cognitive control tasks in overweight children. Design and Methods Participants included 43 unfit, overweight (BMI ≥ 85th percentile) children 8- to 11-years old (91% Black), who were randomly divided into either an aerobic exercise (n = 24) or attention control group (n = 19). Each group was offered a separate instructor-led after-school program every school day for 8 months. Before and after the program, all children performed two cognitive control tasks during functional magnetic resonance imaging (fMRI): antisaccade and flanker. Results Compared to the control group, the exercise group decreased activation in several regions supporting antisaccade performance, including precentral gyrus and posterior parietal cortex, and increased activation in several regions supporting flanker performance, including anterior cingulate and superior frontal gyrus. Conclusions Exercise may differentially impact these two task conditions, or the paradigms in which cognitive control tasks were presented may be sensitive to distinct types of brain activation that show different effects of exercise. In sum, exercise appears to alter efficiency or flexible modulation of neural circuitry supporting cognitive control in overweight children.

Original languageEnglish (US)
Pages (from-to)232-242
Number of pages11
JournalObesity
Volume22
Issue number1
DOIs
StatePublished - Jan 1 2014

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Randomized Controlled Trials
Exercise
Brain
Control Groups
Parietal Lobe
Gyrus Cinguli
Frontal Lobe
Prefrontal Cortex
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Krafft, C. E., Schwarz, N. F., Chi, L., Weinberger, A. L., Schaeffer, D. J., Pierce, J. E., ... McDowell, J. E. (2014). An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity, 22(1), 232-242. https://doi.org/10.1002/oby.20518

An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. / Krafft, Cynthia E.; Schwarz, Nicolette F.; Chi, Lingxi; Weinberger, Abby L.; Schaeffer, David J.; Pierce, Jordan E.; Rodrigue, Amanda L.; Yanasak, Nathan Eugene; Miller, Patricia H.; Tomporowski, Phillip D.; Davis, Catherine Lucy; McDowell, Jennifer E.

In: Obesity, Vol. 22, No. 1, 01.01.2014, p. 232-242.

Research output: Contribution to journalArticle

Krafft, CE, Schwarz, NF, Chi, L, Weinberger, AL, Schaeffer, DJ, Pierce, JE, Rodrigue, AL, Yanasak, NE, Miller, PH, Tomporowski, PD, Davis, CL & McDowell, JE 2014, 'An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children', Obesity, vol. 22, no. 1, pp. 232-242. https://doi.org/10.1002/oby.20518
Krafft CE, Schwarz NF, Chi L, Weinberger AL, Schaeffer DJ, Pierce JE et al. An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity. 2014 Jan 1;22(1):232-242. https://doi.org/10.1002/oby.20518
Krafft, Cynthia E. ; Schwarz, Nicolette F. ; Chi, Lingxi ; Weinberger, Abby L. ; Schaeffer, David J. ; Pierce, Jordan E. ; Rodrigue, Amanda L. ; Yanasak, Nathan Eugene ; Miller, Patricia H. ; Tomporowski, Phillip D. ; Davis, Catherine Lucy ; McDowell, Jennifer E. / An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. In: Obesity. 2014 ; Vol. 22, No. 1. pp. 232-242.
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