An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus

Roni J. Bollag, Zahava Siegfried, Judith A. Cebra-Thomas, Nancy Garvey, Ewa M. Davison, Lee M. Silver

Research output: Contribution to journalArticle

184 Scopus citations

Abstract

The T locus encodes a product with DNA binding activity that is likely to play a role in the development of all vertebrate organisms. We have identified and characterized a novel family of mouse genes that share a protein motif, the T–box, with the prototypical T locus. The T–box domain of the T locus co–localizes with its DNA binding activity. Each T–box gene is expressed in a unique temporal and spatial pattern during embryogenesis. Phylogenetic analysis suggests that at least three T–box genes were present in the common ancestor to vertebrates and invertebrates. Thus, members of the T–box family could have played a role in the evolution of all metazoan organisms.

Original languageEnglish (US)
Pages (from-to)383-389
Number of pages7
JournalNature Genetics
Volume7
Issue number3
DOIs
StatePublished - Jul 1994

ASJC Scopus subject areas

  • Genetics

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