An application of multivariate ranks to assess effects from combining factors

Metal exposures and semen analysis outcomes

R. V. Ramamoorthi, M. G. Rossano, N. Paneth, J. C. Gardiner, Michael Peter Diamond, E. Puscheck, D. C. Daly, R. C. Potter, J. J. Wirth

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In studies of environmental effects on human health outcomes, it is often difficult to assess the effects of a group of exposure variables when the individual exposures do not appear to have statistically significant effects. To address this situation, we propose a method of U-scores applied to subsets of multivariate data. We illustrate the usefulness of this approach by applying it to data collected as part of a study on the effects of metal exposure on human semen parameters. In this analysis, profiles (pairs) of metals containing copper and/or manganese were negatively correlated with total motile sperm and profiles containing copper were negatively correlated with sperm morphology; profiles containing selenium and chromium were positively correlated with total motile sperm.

Original languageEnglish (US)
Pages (from-to)3503-3514
Number of pages12
JournalStatistics in Medicine
Volume27
Issue number18
DOIs
StatePublished - Aug 15 2008
Externally publishedYes

Fingerprint

Semen Analysis
Spermatozoa
Metals
Copper
Chromium
Manganese
Selenium
Semen
Multivariate Data
Health
Subset
Profile
Human

Keywords

  • Environmental health
  • Metals
  • Semen parameters
  • Sperm
  • U-scores

ASJC Scopus subject areas

  • Epidemiology
  • Statistics and Probability

Cite this

An application of multivariate ranks to assess effects from combining factors : Metal exposures and semen analysis outcomes. / Ramamoorthi, R. V.; Rossano, M. G.; Paneth, N.; Gardiner, J. C.; Diamond, Michael Peter; Puscheck, E.; Daly, D. C.; Potter, R. C.; Wirth, J. J.

In: Statistics in Medicine, Vol. 27, No. 18, 15.08.2008, p. 3503-3514.

Research output: Contribution to journalArticle

Ramamoorthi, RV, Rossano, MG, Paneth, N, Gardiner, JC, Diamond, MP, Puscheck, E, Daly, DC, Potter, RC & Wirth, JJ 2008, 'An application of multivariate ranks to assess effects from combining factors: Metal exposures and semen analysis outcomes', Statistics in Medicine, vol. 27, no. 18, pp. 3503-3514. https://doi.org/10.1002/sim.3236
Ramamoorthi, R. V. ; Rossano, M. G. ; Paneth, N. ; Gardiner, J. C. ; Diamond, Michael Peter ; Puscheck, E. ; Daly, D. C. ; Potter, R. C. ; Wirth, J. J. / An application of multivariate ranks to assess effects from combining factors : Metal exposures and semen analysis outcomes. In: Statistics in Medicine. 2008 ; Vol. 27, No. 18. pp. 3503-3514.
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