An assessment of bone fluoride and osteosarcoma

F. M. Kim, C. Hayes, P. L. Williams, G. M. Whitford, K. J. Joshipura, R. N. Hoover, C. W. Douglass

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The association between fluoride and risk for osteosarcoma is controversial. The purpose of this study was to determine if bone fluoride levels are higher in individuals with osteosarcoma. Incident cases of osteosarcoma (N = 137) and tumor controls (N = 51) were identified by orthopedic physicians, and segments of tumor-adjacent bone and iliac crest bone were analyzed for fluoride content. Logistic regression adjusted for age and sex and potential confounders of osteosarcoma was used to estimate odds ratios (OR) and 95% confidence intervals (CI). There was no significant difference in bone fluoride levels between cases and controls. The OR adjusted for age, gender, and a history of broken bones was 1.33 (95% CI: 0.56-3.15). No significant association between bone fluoride levels and osteosarcoma risk was detected in our case-control study, based on controls with other tumor diagnoses.

Original languageEnglish (US)
Pages (from-to)1171-1176
Number of pages6
JournalJournal of Dental Research
Issue number10
StatePublished - Oct 2011


  • bone
  • case-control study
  • epidemiology
  • fluoride
  • oncology
  • osteosarcoma

ASJC Scopus subject areas

  • Dentistry(all)


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