An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese

J. Y. Zhao, M. M. Xiong, W. Huang, H. Wang, J. Zuo, G. D. Wu, Z. Chen, B. Q. Qiang, M. L. Zhang, J. L. Chen, W. Ding, W. T. Yuan, Hongyan Xu, L. Jin, Y. X. Li, Q. Sun, Q. Y. Liu, E. Boerwinkle, F. D. Fang

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses.

Original languageEnglish (US)
Pages (from-to)209-215
Number of pages7
JournalJournal of Molecular Medicine
Volume83
Issue number3
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

Keywords

  • Linkage analysis
  • Type 2 diabetes
  • Whole-genome scan

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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    Zhao, J. Y., Xiong, M. M., Huang, W., Wang, H., Zuo, J., Wu, G. D., Chen, Z., Qiang, B. Q., Zhang, M. L., Chen, J. L., Ding, W., Yuan, W. T., Xu, H., Jin, L., Li, Y. X., Sun, Q., Liu, Q. Y., Boerwinkle, E., & Fang, F. D. (2005). An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese. Journal of Molecular Medicine, 83(3), 209-215. https://doi.org/10.1007/s00109-004-0587-3