TY - JOUR
T1 - An incremental increase in the complexity of peptides bound to class II MHC changes the diversity of positively selected αβ TCRs
AU - Pacholczyk, R.
AU - Kraj, P.
AU - Ignatowicz, L.
PY - 2001/2/15
Y1 - 2001/2/15
N2 - Positive selection of the normal repertoire of TCRs results from low-avidity interactions with a set of self-peptides bound to the MHC molecules expressed by thymic epithelial cells. The contribution of the individual peptide to positive selection remains a matter of debate. Here, for the first time, we show that two covalent class II MHC-peptide complexes positively select different TCRs expressing a common transgenic TCRβ-chain and endogenous TCRα-chains. Simultaneous expression of both Ab-peptide complexes changed the diversity of positively selected TCRs, indicating an additive and possibly synergistic effect of various peptides in this process.
AB - Positive selection of the normal repertoire of TCRs results from low-avidity interactions with a set of self-peptides bound to the MHC molecules expressed by thymic epithelial cells. The contribution of the individual peptide to positive selection remains a matter of debate. Here, for the first time, we show that two covalent class II MHC-peptide complexes positively select different TCRs expressing a common transgenic TCRβ-chain and endogenous TCRα-chains. Simultaneous expression of both Ab-peptide complexes changed the diversity of positively selected TCRs, indicating an additive and possibly synergistic effect of various peptides in this process.
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U2 - 10.4049/jimmunol.166.4.2357
DO - 10.4049/jimmunol.166.4.2357
M3 - Article
C2 - 11160293
AN - SCOPUS:0035865326
SN - 0022-1767
VL - 166
SP - 2357
EP - 2363
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -