An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines

Nisaraporn Suthiwangcharoen, Steven M. Pochini, Daniel P. Sweat, Chad E. Stephens

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A series of 4,9-dihydropyrrolo[2,1-b]quinazolines containing electron withdrawing groups at the 3-position have been prepared by the palladium-catalyzed intramolecular N-arylation of some 2-aminopyrroles having a 2-bromobenzyl group at the N-1 position. Important for success of the reaction is the use of X-phos, a biphenyl mono-phosphine ligand, instead of xantphos, a more standard diphosphine ligand, and the use of t-BuOH as reaction solvent.

Original languageEnglish (US)
Pages (from-to)706-709
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume48
Issue number3
DOIs
StatePublished - May 1 2011

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Quinazolines
phosphine
Ligands
Palladium
Electrons
diphenyl
xantphos

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines. / Suthiwangcharoen, Nisaraporn; Pochini, Steven M.; Sweat, Daniel P.; Stephens, Chad E.

In: Journal of Heterocyclic Chemistry, Vol. 48, No. 3, 01.05.2011, p. 706-709.

Research output: Contribution to journalArticle

Suthiwangcharoen, Nisaraporn ; Pochini, Steven M. ; Sweat, Daniel P. ; Stephens, Chad E. / An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines. In: Journal of Heterocyclic Chemistry. 2011 ; Vol. 48, No. 3. pp. 706-709.
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