An intramolecular N-arylation approach to 3-functionalized 4,9-dihydropyrrolo[2,1-b]quinazolines

Nisaraporn Suthiwangcharoen, Steven M. Pochini, Daniel P. Sweat, Chad E. Stephens

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Abstract

A series of 4,9-dihydropyrrolo[2,1-b]quinazolines containing electron withdrawing groups at the 3-position have been prepared by the palladium-catalyzed intramolecular N-arylation of some 2-aminopyrroles having a 2-bromobenzyl group at the N-1 position. Important for success of the reaction is the use of X-phos, a biphenyl mono-phosphine ligand, instead of xantphos, a more standard diphosphine ligand, and the use of t-BuOH as reaction solvent.

Original languageEnglish (US)
Pages (from-to)706-709
Number of pages4
JournalJournal of Heterocyclic Chemistry
Volume48
Issue number3
DOIs
Publication statusPublished - May 1 2011

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ASJC Scopus subject areas

  • Organic Chemistry

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