An unconventional role of neurotransmission in synapse formation

Wencheng Xiong, Lin Mei

Research output: Contribution to journalShort survey

2 Scopus citations

Abstract

How do presynatic inputs regulate synapse formation? In this issue of Neuron, Lin et al. show that the neurotransmitter acetylcholine decreases the stability of AChR clusters. This dispersing activity, which requires the serine/threonine kinase Cdk5, cooperates with positive signals from motoneurons to ensure high concentration of AChRs at the neuromuscular junction.

Original languageEnglish (US)
Pages (from-to)521-523
Number of pages3
JournalNeuron
Volume46
Issue number4
DOIs
Publication statusPublished - May 19 2005

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ASJC Scopus subject areas

  • Neuroscience(all)

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