Analgesic and anti-inflammatory effects of essential oils of Eucalyptus

Maria J Silva, Worku Abebe, S. M. Sousa, V. G. Duarte, M. I.L. Machado, F. J.A. Matos

Research output: Contribution to journalArticle

270 Citations (Scopus)

Abstract

Many species of the genus Eucalyptus from the Myrtaceae family are used in Brazilian folk medicine for the treatment of various medical conditions such as cold, flue, fever, and bronchial infections. In the current investigation, we evaluated the analgesic and anti-inflammatory effects of essential oil extracts from three species of Eucalyptus employing various standard experimental test models. Using acetic acid-induced writhes in mice and hot plate thermal stimulation in rats, it was shown that the essential oils of Eucalyptus citriodora (EC), Eucalyptus tereticornis (ET), and Eucalyptus globulus (EG) induced analgesic effects in both models, suggesting peripheral and central actions. In addition, essential oil extracts from the three Eucalyptus species produced anti-inflammatory effects, as demonstrated by inhibition of rat paw edema induced by carrageenan and dextran, neutrophil migration into rat peritoneal cavities induced by carrageenan, and vascular permeability induced by carrageenan and histamine. However, no consistent results were observed for some of the parameters evaluated, both in terms of activities and dose-response relationships, reflecting the complex nature of the oil extracts and/or the assay systems used. Taken together, the data suggest that essential oil extracts of EC, ET, and EG possess central and peripheral analgesic effects as well as neutrophil-dependent and independent anti-inflammatory activities. These initial observations provide support for the reported use of the eucalyptus plant in Brazilian folk medicine. Further investigation is warranted for possible development of new classes of analgesic and anti-inflammatory drugs from components of the essential oils of the Eucalyptus species.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalJournal of Ethnopharmacology
Volume89
Issue number2-3
DOIs
StatePublished - Jan 1 2003

Fingerprint

Eucalyptus
Non-Steroidal Anti-Inflammatory Agents
Volatile Oils
Carrageenan
Traditional Medicine
Analgesics
Neutrophils
Anti-Inflammatory Agents
Myrtaceae
Peritoneal Cavity
Capillary Permeability
Dextrans
Acetic Acid
Histamine
Edema
Oils
Fever
Theoretical Models
Hot Temperature

Keywords

  • Analgesic
  • Anti-inflammatory
  • Essential oils
  • Eucalyptus

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. / Silva, Maria J; Abebe, Worku; Sousa, S. M.; Duarte, V. G.; Machado, M. I.L.; Matos, F. J.A.

In: Journal of Ethnopharmacology, Vol. 89, No. 2-3, 01.01.2003, p. 277-283.

Research output: Contribution to journalArticle

Silva, Maria J ; Abebe, Worku ; Sousa, S. M. ; Duarte, V. G. ; Machado, M. I.L. ; Matos, F. J.A. / Analgesic and anti-inflammatory effects of essential oils of Eucalyptus. In: Journal of Ethnopharmacology. 2003 ; Vol. 89, No. 2-3. pp. 277-283.
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