TY - JOUR
T1 - Analysis of MHC-specific peptide motifs
T2 - Applications in immunotherapy
AU - Loftus, D. J.
AU - Kubo, R. T.
AU - Sakaguchi, K.
AU - Celis, E.
AU - Sette, A.
AU - Appella, E.
PY - 1995
Y1 - 1995
N2 - The structural features which underlie peptide binding to MHC molecules permit the binding of a diverse array of peptides. Polymorphic residues of class I, and to a lesser extent, class II molecules, determine the peptide selectivities associated with various allomorphs. The motifs which are described here and elsewhere in the literature mainly reflect peptide features which contribute to high affinity binding. While high affinity MHC binding is not an absolute prerequisite for the immunologic relevance of a peptide, motifs provide general guidelines for eliciting and characterizing cellular responses to epitopes presented by a given MHC allomorph or group of related allomorphs. The utility of motifs is underscored by emerging developments in the clinical application of peptides to elicit specific and effective cellular responses.
AB - The structural features which underlie peptide binding to MHC molecules permit the binding of a diverse array of peptides. Polymorphic residues of class I, and to a lesser extent, class II molecules, determine the peptide selectivities associated with various allomorphs. The motifs which are described here and elsewhere in the literature mainly reflect peptide features which contribute to high affinity binding. While high affinity MHC binding is not an absolute prerequisite for the immunologic relevance of a peptide, motifs provide general guidelines for eliciting and characterizing cellular responses to epitopes presented by a given MHC allomorph or group of related allomorphs. The utility of motifs is underscored by emerging developments in the clinical application of peptides to elicit specific and effective cellular responses.
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U2 - 10.1007/978-1-4615-1891-4_21
DO - 10.1007/978-1-4615-1891-4_21
M3 - Article
C2 - 8644503
AN - SCOPUS:0028826161
SN - 0065-2598
VL - 383
SP - 201
EP - 210
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -