Abstract
The In-111 coincidence camera we previously proposed can significantly increase detection efficiency because collimators are no longer needed. However, the initial simulations indicated that spatial resolution was too poor for medical imaging. To improve the resolution, we derived an analytical deconvolution algorithm in this study. In the derivation, 1-D Fourier transform for the shift-invariant point spread function (PSF) with respect to the detector bin location t was carried out analytically. The Fourier transform is approximately a linear function of the source-to-detector distance s when s is greater than 5 cm and its variation over s is much slower than that of any extensive source. The Fourier transform of the PSF can thus be taken out of the integration over s with reasonable accuracy and its inversion is the deconvolution kernel. A low-pass filter was applied to the deconvolved Fourier transform to suppress high-frequency oscillation. Applying the derived deconvolution algorithm to computer simulated phantoms, we achieved a resolution of 2 cm for s = 10 cm. Compared to the pre-deconvolution resolution of 19 cm, this is a huge improvement but is still poor. The errors caused by the approximations made in the derivation can be further reduced and also the high-frequency behavior of the deconvolved Fourier transform can be improved using better deconvolution techniques. Monte Carlo simulations for more realistic sources with image noise should be performed for further evaluation.
| Original language | English (US) |
|---|---|
| Title of host publication | Medical Imaging 2007 |
| Subtitle of host publication | Physics of Medical Imaging |
| Edition | PART 2 |
| DOIs | |
| State | Published - Oct 15 2007 |
| Event | Medical Imaging 2007: Physics of Medical Imaging - San Diego, CA, United States Duration: Feb 18 2007 → Feb 22 2007 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Number | PART 2 |
| Volume | 6510 |
| ISSN (Print) | 1605-7422 |
Other
| Other | Medical Imaging 2007: Physics of Medical Imaging |
|---|---|
| Country | United States |
| City | San Diego, CA |
| Period | 2/18/07 → 2/22/07 |
Fingerprint
Keywords
- Cascaded photons
- Coincidence detection
- Computer simulation
- Deconvolution
- Spatial resolution
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging
Cite this
Analytical deconvolution for improvement in spatial resolution of the In-111 coincidence camera. / Cao, Zongjian.
Medical Imaging 2007: Physics of Medical Imaging. PART 2. ed. 2007. 65103O (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6510, No. PART 2).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Analytical deconvolution for improvement in spatial resolution of the In-111 coincidence camera
AU - Cao, Zongjian
PY - 2007/10/15
Y1 - 2007/10/15
N2 - The In-111 coincidence camera we previously proposed can significantly increase detection efficiency because collimators are no longer needed. However, the initial simulations indicated that spatial resolution was too poor for medical imaging. To improve the resolution, we derived an analytical deconvolution algorithm in this study. In the derivation, 1-D Fourier transform for the shift-invariant point spread function (PSF) with respect to the detector bin location t was carried out analytically. The Fourier transform is approximately a linear function of the source-to-detector distance s when s is greater than 5 cm and its variation over s is much slower than that of any extensive source. The Fourier transform of the PSF can thus be taken out of the integration over s with reasonable accuracy and its inversion is the deconvolution kernel. A low-pass filter was applied to the deconvolved Fourier transform to suppress high-frequency oscillation. Applying the derived deconvolution algorithm to computer simulated phantoms, we achieved a resolution of 2 cm for s = 10 cm. Compared to the pre-deconvolution resolution of 19 cm, this is a huge improvement but is still poor. The errors caused by the approximations made in the derivation can be further reduced and also the high-frequency behavior of the deconvolved Fourier transform can be improved using better deconvolution techniques. Monte Carlo simulations for more realistic sources with image noise should be performed for further evaluation.
AB - The In-111 coincidence camera we previously proposed can significantly increase detection efficiency because collimators are no longer needed. However, the initial simulations indicated that spatial resolution was too poor for medical imaging. To improve the resolution, we derived an analytical deconvolution algorithm in this study. In the derivation, 1-D Fourier transform for the shift-invariant point spread function (PSF) with respect to the detector bin location t was carried out analytically. The Fourier transform is approximately a linear function of the source-to-detector distance s when s is greater than 5 cm and its variation over s is much slower than that of any extensive source. The Fourier transform of the PSF can thus be taken out of the integration over s with reasonable accuracy and its inversion is the deconvolution kernel. A low-pass filter was applied to the deconvolved Fourier transform to suppress high-frequency oscillation. Applying the derived deconvolution algorithm to computer simulated phantoms, we achieved a resolution of 2 cm for s = 10 cm. Compared to the pre-deconvolution resolution of 19 cm, this is a huge improvement but is still poor. The errors caused by the approximations made in the derivation can be further reduced and also the high-frequency behavior of the deconvolved Fourier transform can be improved using better deconvolution techniques. Monte Carlo simulations for more realistic sources with image noise should be performed for further evaluation.
KW - Cascaded photons
KW - Coincidence detection
KW - Computer simulation
KW - Deconvolution
KW - Spatial resolution
UR - http://www.scopus.com/inward/record.url?scp=35148892407&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35148892407&partnerID=8YFLogxK
U2 - 10.1117/12.712660
DO - 10.1117/12.712660
M3 - Conference contribution
AN - SCOPUS:35148892407
SN - 081946628X
SN - 9780819466280
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2007
ER -