Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer

Daniel Albo, Jeffrey D. Wayne, Kelly K. Hunt, Tom F. Rahlfs, S. Eva Singletary, Frederick C. Ames, Barry W. Feig, Merrick I. Ross, Henry M. Kuerer

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Background: Sentinel lymph node biopsy (SLNB) is an alternative to axillary dissection for many breast cancer patients. Cases of anaphylactic reaction to the isosulfan blue dye used during SLNB have recently been reported. No study on the incidence of serious anaphylactic reactions during SLNB for breast cancer has been reported. Methods: We reviewed 639 consecutive SLNBs for breast cancer performed at our institution. Sentinel lymph node biopsy was performed using both isosulfan blue dye and technetium-99m sulfur colloid. Cases of anaphylaxis were reviewed in detail. Results: Overall, 1.1% of patients had severe anaphylactic reactions to isosulfan blue requiring vigorous resuscitation. No deaths or permanent disability occurred. In patients with anaphylaxis, hospital stay was prolonged by a mean of 1.6 days. In 1 patient, the anaphylactic reaction required termination of the operation. Conclusions: Prompt recognition and aggressive treatment of anaphylactic reactions to isosulfan blue are critical to prevent an adverse outcome. Lymphatic mapping with blue dye should be performed in a setting where personnel are trained to recognize and treat anaphylaxis.

Original languageEnglish (US)
Pages (from-to)393-398
Number of pages6
JournalAmerican Journal of Surgery
Volume182
Issue number4
DOIs
StatePublished - Dec 3 2001
Externally publishedYes

Fingerprint

Sentinel Lymph Node Biopsy
Anaphylaxis
Coloring Agents
Breast Neoplasms
Technetium Tc 99m Sulfur Colloid
iso-sulfan blue
Technetium
Resuscitation
Dissection
Length of Stay
Cohort Studies

Keywords

  • Anaphylaxis
  • Breast cancer
  • Isosulfan blue
  • Sentinel lymph node
  • Surgery

ASJC Scopus subject areas

  • Surgery

Cite this

Albo, D., Wayne, J. D., Hunt, K. K., Rahlfs, T. F., Singletary, S. E., Ames, F. C., ... Kuerer, H. M. (2001). Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. American Journal of Surgery, 182(4), 393-398. https://doi.org/10.1016/S0002-9610(01)00734-6

Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. / Albo, Daniel; Wayne, Jeffrey D.; Hunt, Kelly K.; Rahlfs, Tom F.; Singletary, S. Eva; Ames, Frederick C.; Feig, Barry W.; Ross, Merrick I.; Kuerer, Henry M.

In: American Journal of Surgery, Vol. 182, No. 4, 03.12.2001, p. 393-398.

Research output: Contribution to journalArticle

Albo, D, Wayne, JD, Hunt, KK, Rahlfs, TF, Singletary, SE, Ames, FC, Feig, BW, Ross, MI & Kuerer, HM 2001, 'Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer', American Journal of Surgery, vol. 182, no. 4, pp. 393-398. https://doi.org/10.1016/S0002-9610(01)00734-6
Albo, Daniel ; Wayne, Jeffrey D. ; Hunt, Kelly K. ; Rahlfs, Tom F. ; Singletary, S. Eva ; Ames, Frederick C. ; Feig, Barry W. ; Ross, Merrick I. ; Kuerer, Henry M. / Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. In: American Journal of Surgery. 2001 ; Vol. 182, No. 4. pp. 393-398.
@article{4bccb1ebda324ee58b732e815bd1f622,
title = "Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer",
abstract = "Background: Sentinel lymph node biopsy (SLNB) is an alternative to axillary dissection for many breast cancer patients. Cases of anaphylactic reaction to the isosulfan blue dye used during SLNB have recently been reported. No study on the incidence of serious anaphylactic reactions during SLNB for breast cancer has been reported. Methods: We reviewed 639 consecutive SLNBs for breast cancer performed at our institution. Sentinel lymph node biopsy was performed using both isosulfan blue dye and technetium-99m sulfur colloid. Cases of anaphylaxis were reviewed in detail. Results: Overall, 1.1{\%} of patients had severe anaphylactic reactions to isosulfan blue requiring vigorous resuscitation. No deaths or permanent disability occurred. In patients with anaphylaxis, hospital stay was prolonged by a mean of 1.6 days. In 1 patient, the anaphylactic reaction required termination of the operation. Conclusions: Prompt recognition and aggressive treatment of anaphylactic reactions to isosulfan blue are critical to prevent an adverse outcome. Lymphatic mapping with blue dye should be performed in a setting where personnel are trained to recognize and treat anaphylaxis.",
keywords = "Anaphylaxis, Breast cancer, Isosulfan blue, Sentinel lymph node, Surgery",
author = "Daniel Albo and Wayne, {Jeffrey D.} and Hunt, {Kelly K.} and Rahlfs, {Tom F.} and Singletary, {S. Eva} and Ames, {Frederick C.} and Feig, {Barry W.} and Ross, {Merrick I.} and Kuerer, {Henry M.}",
year = "2001",
month = "12",
day = "3",
doi = "10.1016/S0002-9610(01)00734-6",
language = "English (US)",
volume = "182",
pages = "393--398",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer

AU - Albo, Daniel

AU - Wayne, Jeffrey D.

AU - Hunt, Kelly K.

AU - Rahlfs, Tom F.

AU - Singletary, S. Eva

AU - Ames, Frederick C.

AU - Feig, Barry W.

AU - Ross, Merrick I.

AU - Kuerer, Henry M.

PY - 2001/12/3

Y1 - 2001/12/3

N2 - Background: Sentinel lymph node biopsy (SLNB) is an alternative to axillary dissection for many breast cancer patients. Cases of anaphylactic reaction to the isosulfan blue dye used during SLNB have recently been reported. No study on the incidence of serious anaphylactic reactions during SLNB for breast cancer has been reported. Methods: We reviewed 639 consecutive SLNBs for breast cancer performed at our institution. Sentinel lymph node biopsy was performed using both isosulfan blue dye and technetium-99m sulfur colloid. Cases of anaphylaxis were reviewed in detail. Results: Overall, 1.1% of patients had severe anaphylactic reactions to isosulfan blue requiring vigorous resuscitation. No deaths or permanent disability occurred. In patients with anaphylaxis, hospital stay was prolonged by a mean of 1.6 days. In 1 patient, the anaphylactic reaction required termination of the operation. Conclusions: Prompt recognition and aggressive treatment of anaphylactic reactions to isosulfan blue are critical to prevent an adverse outcome. Lymphatic mapping with blue dye should be performed in a setting where personnel are trained to recognize and treat anaphylaxis.

AB - Background: Sentinel lymph node biopsy (SLNB) is an alternative to axillary dissection for many breast cancer patients. Cases of anaphylactic reaction to the isosulfan blue dye used during SLNB have recently been reported. No study on the incidence of serious anaphylactic reactions during SLNB for breast cancer has been reported. Methods: We reviewed 639 consecutive SLNBs for breast cancer performed at our institution. Sentinel lymph node biopsy was performed using both isosulfan blue dye and technetium-99m sulfur colloid. Cases of anaphylaxis were reviewed in detail. Results: Overall, 1.1% of patients had severe anaphylactic reactions to isosulfan blue requiring vigorous resuscitation. No deaths or permanent disability occurred. In patients with anaphylaxis, hospital stay was prolonged by a mean of 1.6 days. In 1 patient, the anaphylactic reaction required termination of the operation. Conclusions: Prompt recognition and aggressive treatment of anaphylactic reactions to isosulfan blue are critical to prevent an adverse outcome. Lymphatic mapping with blue dye should be performed in a setting where personnel are trained to recognize and treat anaphylaxis.

KW - Anaphylaxis

KW - Breast cancer

KW - Isosulfan blue

KW - Sentinel lymph node

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=0035175475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035175475&partnerID=8YFLogxK

U2 - 10.1016/S0002-9610(01)00734-6

DO - 10.1016/S0002-9610(01)00734-6

M3 - Article

C2 - 11720678

AN - SCOPUS:0035175475

VL - 182

SP - 393

EP - 398

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 4

ER -