Anatomy of an endogenous antagonist

relationship between Agouti-related protein and proopiomelanocortin in brain.

D. Bagnol, Xinyun Lu, C. B. Kaelin, H. E. Day, M. Ollmann, I. Gantz, H. Akil, G. S. Barsh, S. J. Watson

Research output: Contribution to journalArticle

260 Citations (Scopus)

Abstract

Agouti-related protein (AGRP) is a recently discovered orexigenic neuropeptide that inhibits the binding and action of alpha-melanocyte-stimulating hormone derived from proopiomelanocortin (POMC) at the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) and has been proposed to function primarily as an endogenous melanocortin antagonist. To better understand the interplay between the AGRP and melanocortin signaling systems, we compared their nerve fiber distributions with each other by immunohistochemistry and their perikarya distribution with MC3R and MC4R by double in situ hybridization. Although deriving from distinct cell groups, AGRP and melanocortin terminals project to identical brain areas. Both AGRP and melanocortin neurons selectively express the MC3R, which provides a neuroanatomical basis for a dual-input circuit with biological amplification and feedback inhibition. These studies highlight a broader complexity in POMC-mediated behavior in the brain.

Original languageEnglish (US)
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume19
Issue number18
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Agouti-Related Protein
Melanocortins
Pro-Opiomelanocortin
Receptor, Melanocortin, Type 3
Anatomy
Receptor, Melanocortin, Type 4
Brain
alpha-MSH
Neuropeptides
Nerve Fibers
In Situ Hybridization
Immunohistochemistry
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Anatomy of an endogenous antagonist : relationship between Agouti-related protein and proopiomelanocortin in brain. / Bagnol, D.; Lu, Xinyun; Kaelin, C. B.; Day, H. E.; Ollmann, M.; Gantz, I.; Akil, H.; Barsh, G. S.; Watson, S. J.

In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, No. 18, 01.01.1999.

Research output: Contribution to journalArticle

Bagnol, D. ; Lu, Xinyun ; Kaelin, C. B. ; Day, H. E. ; Ollmann, M. ; Gantz, I. ; Akil, H. ; Barsh, G. S. ; Watson, S. J. / Anatomy of an endogenous antagonist : relationship between Agouti-related protein and proopiomelanocortin in brain. In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 ; Vol. 19, No. 18.
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