Androgenic maintenance of the erectile response in the rat

Thomas M. Mills, Yutian Dai, Vivienne S. Stopper, Ronald W Lewis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Ongoing studies in this laboratory have used the castrated rat, with and without testosterone replacement, to investigate how androgens maintain the erectile response. The high intracavernosal pressures during erection depend on both an increase in the rate at which blood flows into the sinuses of the corpus cavernosum and a decrease in the rate at which blood flows out (veno-occlusion). Accordingly, our studies investigated androgenic regulation of the arterioles that regulate inflow and of the intracavernosal muscle that regulates the veno-occlusive mechanism controlling outflow. The results of these studies show that castration causes a decline in the rate of inflow and that androgen replacement reverses this decline. The decline in inflow in the castrated rats is also reversed by the administration of a nitric oxide donor drug, suggesting that the androgen may regulate inflow by increasing the synthesis of nitric oxide. Testosterone also appears to regulate outflow by controlling the sensitivity of the erectile mechanisms to norepinephrine, considered to be the principle vaso-constrictor neurotransmitter in the erectile response. Taken together, the results of these studies suggest that androgens control the erectile response by altering the synthesis and action of the neurotransmitters that normally alter the state of contraction and relaxation of smooth muscle in the erectile tissue. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)605-609
Number of pages5
JournalSteroids
Volume64
Issue number9
DOIs
StatePublished - Jan 1 1999

Fingerprint

Androgens
Rats
Maintenance
Neurotransmitter Agents
Muscle
Testosterone
Blood
Nitric Oxide Donors
Castration
Arterioles
Smooth Muscle
Norepinephrine
Nitric Oxide
Tissue
Pressure
Muscles
Pharmaceutical Preparations

Keywords

  • Blood flow
  • Nitric oxide
  • Norepinephrine
  • Penile erection
  • Testosterone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Mills, T. M., Dai, Y., Stopper, V. S., & Lewis, R. W. (1999). Androgenic maintenance of the erectile response in the rat. Steroids, 64(9), 605-609. https://doi.org/10.1016/S0039-128X(99)00040-9

Androgenic maintenance of the erectile response in the rat. / Mills, Thomas M.; Dai, Yutian; Stopper, Vivienne S.; Lewis, Ronald W.

In: Steroids, Vol. 64, No. 9, 01.01.1999, p. 605-609.

Research output: Contribution to journalArticle

Mills, TM, Dai, Y, Stopper, VS & Lewis, RW 1999, 'Androgenic maintenance of the erectile response in the rat', Steroids, vol. 64, no. 9, pp. 605-609. https://doi.org/10.1016/S0039-128X(99)00040-9
Mills, Thomas M. ; Dai, Yutian ; Stopper, Vivienne S. ; Lewis, Ronald W. / Androgenic maintenance of the erectile response in the rat. In: Steroids. 1999 ; Vol. 64, No. 9. pp. 605-609.
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