Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle

Brian D. Duscha, Jennifer L. Robbins, Christopher D. Kontos, William E. Kraus, Brian H. Annex

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities causing claudication, exercise intolerance and a decreased quality of life. Despite the fact that stenosis of conduit vessels are largely responsible for PAD diagnosis, and re-vascularization of these arteries are routinely performed as a treatment strategy, hemodynamics of conduit vessels do not entirely explain the functional limitation observed in PAD patients. Due to the inherent purpose the microvasculature plays in blood delivery and oxygen exchange to skeletal muscle, angiogenesis of the microvasculature may play a prominent role in PAD and has become the focus of both basic science and a therapeutic target for PAD clinical trials. This review will discuss what is currently known about skeletal muscle capillary density in PAD patients compared to normal subjects, how capillary density relates to exercise intolerance and how exercise training may be the best therapeutic intervention for initiating angiogenesis to improve exercise tolerance. Last, we will discuss the mechanisms of angiogenesis in skeletal muscle and the use of growth factors in therapeutic clinical trials.

Original languageEnglish (US)
Title of host publicationAngiogenesis
Subtitle of host publicationInsights from a Systematic Overview
PublisherNova Science Publishers, Inc.
Pages99-134
Number of pages36
ISBN (Print)9781626181144
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Peripheral Arterial Disease
Muscle
Skeletal Muscle
Exercise
Microvessels
Blood
Therapeutics
Clinical Trials
Exercise Tolerance
Hemodynamics
Lower Extremity
Intercellular Signaling Peptides and Proteins
Pathologic Constriction
Arteries
Quality of Life
Oxygen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Duscha, B. D., Robbins, J. L., Kontos, C. D., Kraus, W. E., & Annex, B. H. (2013). Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle. In Angiogenesis: Insights from a Systematic Overview (pp. 99-134). Nova Science Publishers, Inc..

Angiogenesis in peripheral artery disease : An emerging therapy targeting skeletal muscle. / Duscha, Brian D.; Robbins, Jennifer L.; Kontos, Christopher D.; Kraus, William E.; Annex, Brian H.

Angiogenesis: Insights from a Systematic Overview. Nova Science Publishers, Inc., 2013. p. 99-134.

Research output: Chapter in Book/Report/Conference proceedingChapter

Duscha, BD, Robbins, JL, Kontos, CD, Kraus, WE & Annex, BH 2013, Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle. in Angiogenesis: Insights from a Systematic Overview. Nova Science Publishers, Inc., pp. 99-134.
Duscha BD, Robbins JL, Kontos CD, Kraus WE, Annex BH. Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle. In Angiogenesis: Insights from a Systematic Overview. Nova Science Publishers, Inc. 2013. p. 99-134
Duscha, Brian D. ; Robbins, Jennifer L. ; Kontos, Christopher D. ; Kraus, William E. ; Annex, Brian H. / Angiogenesis in peripheral artery disease : An emerging therapy targeting skeletal muscle. Angiogenesis: Insights from a Systematic Overview. Nova Science Publishers, Inc., 2013. pp. 99-134
@inbook{4171badeafa0473bbf81e63305916e0e,
title = "Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle",
abstract = "Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities causing claudication, exercise intolerance and a decreased quality of life. Despite the fact that stenosis of conduit vessels are largely responsible for PAD diagnosis, and re-vascularization of these arteries are routinely performed as a treatment strategy, hemodynamics of conduit vessels do not entirely explain the functional limitation observed in PAD patients. Due to the inherent purpose the microvasculature plays in blood delivery and oxygen exchange to skeletal muscle, angiogenesis of the microvasculature may play a prominent role in PAD and has become the focus of both basic science and a therapeutic target for PAD clinical trials. This review will discuss what is currently known about skeletal muscle capillary density in PAD patients compared to normal subjects, how capillary density relates to exercise intolerance and how exercise training may be the best therapeutic intervention for initiating angiogenesis to improve exercise tolerance. Last, we will discuss the mechanisms of angiogenesis in skeletal muscle and the use of growth factors in therapeutic clinical trials.",
author = "Duscha, {Brian D.} and Robbins, {Jennifer L.} and Kontos, {Christopher D.} and Kraus, {William E.} and Annex, {Brian H.}",
year = "2013",
month = "12",
day = "1",
language = "English (US)",
isbn = "9781626181144",
pages = "99--134",
booktitle = "Angiogenesis",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Angiogenesis in peripheral artery disease

T2 - An emerging therapy targeting skeletal muscle

AU - Duscha, Brian D.

AU - Robbins, Jennifer L.

AU - Kontos, Christopher D.

AU - Kraus, William E.

AU - Annex, Brian H.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities causing claudication, exercise intolerance and a decreased quality of life. Despite the fact that stenosis of conduit vessels are largely responsible for PAD diagnosis, and re-vascularization of these arteries are routinely performed as a treatment strategy, hemodynamics of conduit vessels do not entirely explain the functional limitation observed in PAD patients. Due to the inherent purpose the microvasculature plays in blood delivery and oxygen exchange to skeletal muscle, angiogenesis of the microvasculature may play a prominent role in PAD and has become the focus of both basic science and a therapeutic target for PAD clinical trials. This review will discuss what is currently known about skeletal muscle capillary density in PAD patients compared to normal subjects, how capillary density relates to exercise intolerance and how exercise training may be the best therapeutic intervention for initiating angiogenesis to improve exercise tolerance. Last, we will discuss the mechanisms of angiogenesis in skeletal muscle and the use of growth factors in therapeutic clinical trials.

AB - Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities causing claudication, exercise intolerance and a decreased quality of life. Despite the fact that stenosis of conduit vessels are largely responsible for PAD diagnosis, and re-vascularization of these arteries are routinely performed as a treatment strategy, hemodynamics of conduit vessels do not entirely explain the functional limitation observed in PAD patients. Due to the inherent purpose the microvasculature plays in blood delivery and oxygen exchange to skeletal muscle, angiogenesis of the microvasculature may play a prominent role in PAD and has become the focus of both basic science and a therapeutic target for PAD clinical trials. This review will discuss what is currently known about skeletal muscle capillary density in PAD patients compared to normal subjects, how capillary density relates to exercise intolerance and how exercise training may be the best therapeutic intervention for initiating angiogenesis to improve exercise tolerance. Last, we will discuss the mechanisms of angiogenesis in skeletal muscle and the use of growth factors in therapeutic clinical trials.

UR - http://www.scopus.com/inward/record.url?scp=84887848754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887848754&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:84887848754

SN - 9781626181144

SP - 99

EP - 134

BT - Angiogenesis

PB - Nova Science Publishers, Inc.

ER -