Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle

Brian D. Duscha, Jennifer L. Robbins, Christopher D. Kontos, William E. Kraus, Brian H. Annex

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Peripheral artery disease (PAD) is characterized by impaired blood flow to the lower extremities causing claudication, exercise intolerance and a decreased quality of life. Despite the fact that stenosis of conduit vessels are largely responsible for PAD diagnosis, and re-vascularization of these arteries are routinely performed as a treatment strategy, hemodynamics of conduit vessels do not entirely explain the functional limitation observed in PAD patients. Due to the inherent purpose the microvasculature plays in blood delivery and oxygen exchange to skeletal muscle, angiogenesis of the microvasculature may play a prominent role in PAD and has become the focus of both basic science and a therapeutic target for PAD clinical trials. This review will discuss what is currently known about skeletal muscle capillary density in PAD patients compared to normal subjects, how capillary density relates to exercise intolerance and how exercise training may be the best therapeutic intervention for initiating angiogenesis to improve exercise tolerance. Last, we will discuss the mechanisms of angiogenesis in skeletal muscle and the use of growth factors in therapeutic clinical trials.

Original languageEnglish (US)
Title of host publicationAngiogenesis
Subtitle of host publicationInsights from a Systematic Overview
PublisherNova Science Publishers, Inc.
Pages99-134
Number of pages36
ISBN (Print)9781626181144
StatePublished - Dec 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Duscha, B. D., Robbins, J. L., Kontos, C. D., Kraus, W. E., & Annex, B. H. (2013). Angiogenesis in peripheral artery disease: An emerging therapy targeting skeletal muscle. In Angiogenesis: Insights from a Systematic Overview (pp. 99-134). Nova Science Publishers, Inc..