Angiomyogenesis for myocardial repair

Husnain Kh Haider, Syed Ali Akbar, Muhammad Ashraf

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The conventional therapeutic modalities for myocardial infarction have limited success in preventing the progression of left ventricular remodeling and congestive heart failure. The heart cell therapy and therapeutic angiogenesis are two promising strategies for the treatment of ischemic heart disease. After extensive assessment of safety and effectiveness in vitro and in experimental animal studies, both of these approaches have accomplished the stage of clinical utility, albeit with limited success due to the inherent limitations and problems of each approach. Neomyogenesis without restoration of regional blood flow may be less meaningful. A combined stem-cell and gene-therapy approach of angiomyogenesis is expected to yield better results as compared with either of the approaches as a monotherapy. The combined therapy approach will help to restore the mechanical contractile function of the weakened myocardium and alleviate ischemic condition by restoration of regional blood flow. In providing an overview of both stem cell therapy and gene therapy, this article is an in-depth and critical appreciation of combined cell and gene therapy approach for myocardial repair.

Original languageEnglish (US)
Pages (from-to)1929-1944
Number of pages16
JournalAntioxidants and Redox Signaling
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2009

Fingerprint

Gene therapy
Cell- and Tissue-Based Therapy
Repair
Genetic Therapy
Stem cells
Restoration
Regional Blood Flow
Blood
Stem Cells
Ventricular Remodeling
Animals
Therapeutics
Myocardial Ischemia
Myocardium
Heart Failure
Myocardial Infarction
Safety

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Angiomyogenesis for myocardial repair. / Haider, Husnain Kh; Akbar, Syed Ali; Ashraf, Muhammad.

In: Antioxidants and Redox Signaling, Vol. 11, No. 8, 01.08.2009, p. 1929-1944.

Research output: Contribution to journalReview article

Haider, Husnain Kh ; Akbar, Syed Ali ; Ashraf, Muhammad. / Angiomyogenesis for myocardial repair. In: Antioxidants and Redox Signaling. 2009 ; Vol. 11, No. 8. pp. 1929-1944.
@article{98d015ded2bc4168a4121c256b3f1691,
title = "Angiomyogenesis for myocardial repair",
abstract = "The conventional therapeutic modalities for myocardial infarction have limited success in preventing the progression of left ventricular remodeling and congestive heart failure. The heart cell therapy and therapeutic angiogenesis are two promising strategies for the treatment of ischemic heart disease. After extensive assessment of safety and effectiveness in vitro and in experimental animal studies, both of these approaches have accomplished the stage of clinical utility, albeit with limited success due to the inherent limitations and problems of each approach. Neomyogenesis without restoration of regional blood flow may be less meaningful. A combined stem-cell and gene-therapy approach of angiomyogenesis is expected to yield better results as compared with either of the approaches as a monotherapy. The combined therapy approach will help to restore the mechanical contractile function of the weakened myocardium and alleviate ischemic condition by restoration of regional blood flow. In providing an overview of both stem cell therapy and gene therapy, this article is an in-depth and critical appreciation of combined cell and gene therapy approach for myocardial repair.",
author = "Haider, {Husnain Kh} and Akbar, {Syed Ali} and Muhammad Ashraf",
year = "2009",
month = "8",
day = "1",
doi = "10.1089/ars.2009.2471",
language = "English (US)",
volume = "11",
pages = "1929--1944",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "8",

}

TY - JOUR

T1 - Angiomyogenesis for myocardial repair

AU - Haider, Husnain Kh

AU - Akbar, Syed Ali

AU - Ashraf, Muhammad

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The conventional therapeutic modalities for myocardial infarction have limited success in preventing the progression of left ventricular remodeling and congestive heart failure. The heart cell therapy and therapeutic angiogenesis are two promising strategies for the treatment of ischemic heart disease. After extensive assessment of safety and effectiveness in vitro and in experimental animal studies, both of these approaches have accomplished the stage of clinical utility, albeit with limited success due to the inherent limitations and problems of each approach. Neomyogenesis without restoration of regional blood flow may be less meaningful. A combined stem-cell and gene-therapy approach of angiomyogenesis is expected to yield better results as compared with either of the approaches as a monotherapy. The combined therapy approach will help to restore the mechanical contractile function of the weakened myocardium and alleviate ischemic condition by restoration of regional blood flow. In providing an overview of both stem cell therapy and gene therapy, this article is an in-depth and critical appreciation of combined cell and gene therapy approach for myocardial repair.

AB - The conventional therapeutic modalities for myocardial infarction have limited success in preventing the progression of left ventricular remodeling and congestive heart failure. The heart cell therapy and therapeutic angiogenesis are two promising strategies for the treatment of ischemic heart disease. After extensive assessment of safety and effectiveness in vitro and in experimental animal studies, both of these approaches have accomplished the stage of clinical utility, albeit with limited success due to the inherent limitations and problems of each approach. Neomyogenesis without restoration of regional blood flow may be less meaningful. A combined stem-cell and gene-therapy approach of angiomyogenesis is expected to yield better results as compared with either of the approaches as a monotherapy. The combined therapy approach will help to restore the mechanical contractile function of the weakened myocardium and alleviate ischemic condition by restoration of regional blood flow. In providing an overview of both stem cell therapy and gene therapy, this article is an in-depth and critical appreciation of combined cell and gene therapy approach for myocardial repair.

UR - http://www.scopus.com/inward/record.url?scp=67650251538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650251538&partnerID=8YFLogxK

U2 - 10.1089/ars.2009.2471

DO - 10.1089/ars.2009.2471

M3 - Review article

C2 - 19361254

AN - SCOPUS:67650251538

VL - 11

SP - 1929

EP - 1944

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 8

ER -