Angiopoietins as promising biomarkers and potential therapeutic targets in brain injury

Prashant Chittiboina, Vijay Ganta, Christopher P. Monceaux, L. Keith Scott, Anil Nanda, J. Steven Alexander

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Traumatic brain injury (TBI) and sub-arachnoid hemorrhage (SAH) are major causes of long-term disability, mortality, and enormous economic costs to society. The full spectrum of neurological damage created by TBI or SAH is not usually manifested at the time of injury, but evolves gradually over the course of hours to days (or weeks) following these injuries. Angiopoietins, important regulators of vascular structure and function, are hallmark indicators of vascular injury and may therefore represent promising targets in the treatment of SAH and TBI. In animal models and human tissues, normal intracerebral and pial vessels show strong expression of Angiopoietin-1 (Ang-1), but only minimal expression or presentation of Angiopoietin-2 (Ang-2). After several types of neurotrauma, the ratios of Ang-1 and Ang-2 expression in brain microvessel are disturbed and appear to contribute to the remarkable loss of blood-brain barrier (BBB) in these injuries. Angiopoietins levels, and perhaps more importantly, Angiopoietin ratios (1:2) may have novel and important diagnostic and prognostic uses in TBI and SAH brain injury. Ang-1/2 evaluation in plasma, serum and cerebrospinal fluid may provide new therapeutic modalities which can modify 'secondary' forms of brain injury after TBI and SAH.

Original languageEnglish (US)
Pages (from-to)15-21
Number of pages7
JournalPathophysiology
Volume20
Issue number1
DOIs
StatePublished - Feb 2013
Externally publishedYes

Keywords

  • Angiopoietin
  • Biomarker
  • Brain injury
  • Subarachnoid hemorrhage
  • Traumatic brain injury

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Physiology (medical)

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