Angiotensin II-induced signaling pathways in diabetes.

Mario B. Marrero, David J Fulton, David W Stepp, David M. Stern

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Excessive cellular proliferation is a major contributor to the pathological changes associated with the secondary complications of diabetes. In particular, hyperglycemia (HG)-induced growth of vascular smooth muscle cells (VSMC) and glomerular mesangial cells (GMC) are characteristic features of the cardiovascular and renal complications of diabetes. VSMC and GMC respond to traditional growth factors, however in diabetes this occurs in the context of an environment, enriched in circulating vasoactive mediators and HG. For example, signaling via the angiotensin II (Ang II) pathway has been implicated in the pathogenesis of diabetic vascular disease. Recent findings indicate that HG and Ang II activate intracellular processes, including the polyol pathway and the generation of reactive oxygen species. These pathways activate the JAK (janus kinase)/STAT (signal transducers and activators of transcription) signaling cascades in both VSMC and GMC. Activation of the latter signaling cascade can stimulate excessive proliferation and growth of these cells, contributing to the accelerated atherosclerosis and nephropathy seen in the diabetic state. This review focuses on key factors in the diabetic microenvironment, in particular the interplay between HG, accumulation of advanced glycation end products and Ang II mediated signaling events both in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalCurrent Diabetes Reviews
Volume1
Issue number2
StatePublished - May 1 2005

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Angiotensin II
Hyperglycemia
Mesangial Cells
Vascular Smooth Muscle
Smooth Muscle Myocytes
Diabetes Complications
Cell Proliferation
Janus Kinases
Diabetic Angiopathies
Advanced Glycosylation End Products
Growth
Transducers
Reactive Oxygen Species
Atherosclerosis
Intercellular Signaling Peptides and Proteins
Kidney

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Angiotensin II-induced signaling pathways in diabetes. / Marrero, Mario B.; Fulton, David J; Stepp, David W; Stern, David M.

In: Current Diabetes Reviews, Vol. 1, No. 2, 01.05.2005, p. 197-202.

Research output: Contribution to journalReview article

Marrero, Mario B. ; Fulton, David J ; Stepp, David W ; Stern, David M. / Angiotensin II-induced signaling pathways in diabetes. In: Current Diabetes Reviews. 2005 ; Vol. 1, No. 2. pp. 197-202.
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