Abstract
Post stroke cognitive impairment (PSCI) is an understudied, long-term complication of stroke, impacting nearly 30–40% of all stroke survivors. No cure is available once the cognitive deterioration manifests. To our knowledge, this is the first study to investigate the long-term effects of C21 treatment on the development of PSCI in aged animals. Treatments with C21 or vehicle were administered orally, 24 h post-stroke, and continued for 30 days. Outcome measures for sensorimotor and cognitive function were performed using a sequence of tests, all blindly conducted and assessed at baseline as well as at different time points post-stroke. Our findings demonstrate that the angiotensin receptor (AT2R) agonist C21 effectively prevents the development of PSCI in aged animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 560-569 |
| Number of pages | 10 |
| Journal | Behavioural Brain Research |
| Volume | 359 |
| DOIs | |
| State | Published - Feb 1 2019 |
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Keywords
- AT2 receptor
- Compound 21
- Permanent stroke
- Post-stroke cognitive impairment
- RAS modulation
ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals—A randomized double- blind pre-clinical study. / Ahmed, Heba A.; Ishrat, Tauheed; Pillai, Bindu; Bunting, Kristopher M.; Vazdarjanova, Almira Ivanova; Waller, Jennifer L; Ergul, Adviye; Fagan, Susan C.
In: Behavioural Brain Research, Vol. 359, 01.02.2019, p. 560-569.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals—A randomized double- blind pre-clinical study
AU - Ahmed, Heba A.
AU - Ishrat, Tauheed
AU - Pillai, Bindu
AU - Bunting, Kristopher M.
AU - Vazdarjanova, Almira Ivanova
AU - Waller, Jennifer L
AU - Ergul, Adviye
AU - Fagan, Susan C.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Post stroke cognitive impairment (PSCI) is an understudied, long-term complication of stroke, impacting nearly 30–40% of all stroke survivors. No cure is available once the cognitive deterioration manifests. To our knowledge, this is the first study to investigate the long-term effects of C21 treatment on the development of PSCI in aged animals. Treatments with C21 or vehicle were administered orally, 24 h post-stroke, and continued for 30 days. Outcome measures for sensorimotor and cognitive function were performed using a sequence of tests, all blindly conducted and assessed at baseline as well as at different time points post-stroke. Our findings demonstrate that the angiotensin receptor (AT2R) agonist C21 effectively prevents the development of PSCI in aged animals.
AB - Post stroke cognitive impairment (PSCI) is an understudied, long-term complication of stroke, impacting nearly 30–40% of all stroke survivors. No cure is available once the cognitive deterioration manifests. To our knowledge, this is the first study to investigate the long-term effects of C21 treatment on the development of PSCI in aged animals. Treatments with C21 or vehicle were administered orally, 24 h post-stroke, and continued for 30 days. Outcome measures for sensorimotor and cognitive function were performed using a sequence of tests, all blindly conducted and assessed at baseline as well as at different time points post-stroke. Our findings demonstrate that the angiotensin receptor (AT2R) agonist C21 effectively prevents the development of PSCI in aged animals.
KW - AT2 receptor
KW - Compound 21
KW - Permanent stroke
KW - Post-stroke cognitive impairment
KW - RAS modulation
UR - http://www.scopus.com/inward/record.url?scp=85055256053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055256053&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2018.10.010
DO - 10.1016/j.bbr.2018.10.010
M3 - Article
VL - 359
SP - 560
EP - 569
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -