TY - JOUR
T1 - Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals—A randomized double- blind pre-clinical study
AU - Ahmed, Heba A.
AU - Ishrat, Tauheed
AU - Pillai, Bindu
AU - Bunting, Kristopher M.
AU - Vazdarjanova, Almira
AU - Waller, Jennifer L.
AU - Ergul, Adviye
AU - Fagan, Susan C.
N1 - Funding Information:
This study was supported by R21-NS088016, VA Merit Review (BX000891), RO1-NS063965 to Susan C Fagan and by VA Merit Review (BX000347), VA Research Career Scientist Award, and R01NS083559 to Adviye Ergul.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Post stroke cognitive impairment (PSCI) is an understudied, long-term complication of stroke, impacting nearly 30–40% of all stroke survivors. No cure is available once the cognitive deterioration manifests. To our knowledge, this is the first study to investigate the long-term effects of C21 treatment on the development of PSCI in aged animals. Treatments with C21 or vehicle were administered orally, 24 h post-stroke, and continued for 30 days. Outcome measures for sensorimotor and cognitive function were performed using a sequence of tests, all blindly conducted and assessed at baseline as well as at different time points post-stroke. Our findings demonstrate that the angiotensin receptor (AT2R) agonist C21 effectively prevents the development of PSCI in aged animals.
AB - Post stroke cognitive impairment (PSCI) is an understudied, long-term complication of stroke, impacting nearly 30–40% of all stroke survivors. No cure is available once the cognitive deterioration manifests. To our knowledge, this is the first study to investigate the long-term effects of C21 treatment on the development of PSCI in aged animals. Treatments with C21 or vehicle were administered orally, 24 h post-stroke, and continued for 30 days. Outcome measures for sensorimotor and cognitive function were performed using a sequence of tests, all blindly conducted and assessed at baseline as well as at different time points post-stroke. Our findings demonstrate that the angiotensin receptor (AT2R) agonist C21 effectively prevents the development of PSCI in aged animals.
KW - AT2 receptor
KW - Compound 21
KW - Permanent stroke
KW - Post-stroke cognitive impairment
KW - RAS modulation
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U2 - 10.1016/j.bbr.2018.10.010
DO - 10.1016/j.bbr.2018.10.010
M3 - Article
C2 - 30296528
AN - SCOPUS:85055256053
VL - 359
SP - 560
EP - 569
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -