Animal models of osteomyelitis. Knowledge, hypothesis, and speculation.

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Each animal model has provided insights. Particularly important was the considerable resistance of bone to infection without manipulation (no morrhuate, fracture, rod, wax, or prosthesis). Such perturbations allow bone infection with much smaller inocula. Typical inocula decreases are 1000 to 10,000 fold. Staphylococci may have a selective advantage in bone because of specialized or tropic binding, perhaps to cartilage or collagen. Osteoclast-induced resorption of hydroxyapatite might explain the distribution of some osteomyelitis. Increased osteoclast activity could link the susceptible metaphyseal regions, the repetitively traumatized diabetic foot, a history of blunt bone trauma, fracture, and perhaps even nearby soft tissue infection. Diagnosis remains difficult; gallium-67 and indium111 labeled WBC probably deserve additional investigation. Therapeutic failures in the rabbit and rat models mirror clinical experience. Clindamycin, rifampin, and quinolones are promising. Neither systemic nor local antimicrobial prophylaxis is well studied yet.

Original languageEnglish (US)
Pages (from-to)377-390
Number of pages14
JournalInfectious Disease Clinics of North America
Volume4
Issue number3
StatePublished - Sep 1 1990

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Osteomyelitis
Animal Models
Osteoclasts
Bone and Bones
Soft Tissue Infections
Gallium
Diabetic Foot
Clindamycin
Waxes
Quinolones
Bone Fractures
Durapatite
Rifampin
Infection
Staphylococcus
Prostheses and Implants
Rabbits
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Animal models of osteomyelitis. Knowledge, hypothesis, and speculation. / Rissing, J. P.

In: Infectious Disease Clinics of North America, Vol. 4, No. 3, 01.09.1990, p. 377-390.

Research output: Contribution to journalReview article

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