Anthocyanin-rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet

Jayanta M. Sankhari, Menaka Thounaojam, Ravirajsinh N. Jadeja, Ranjitsinh V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background: Oxidative stress induced by reactive oxygen species plays an important role in the aetiology of several diseases including atherosclerosis and coronary heart disease. Anthocyanin-rich extracts have been shown to possess a variety of therapeutic roles, including antioxidant, cardioprotective and hepatoprotective properties. The present inventory was undertaken to evaluate the protective role of anthocyanin-rich red cabbage extract (ARCE) on an atherogenic (ATH) diet-induced hypercholesterolaemia and related cardiac and, hepatic oxidative stress in rats. Results: ARCE (100 mg kg -1 body weight) treatment of rats fed the ATH diet significantly prevented elevation in serum and tissue lipids, circulating levels of cardiac and hepatic damage markers, and resulted in excretion of lipids through faeces. Also, the ARCE extract significantly attenuated alterations in the cardiac and hepatic antioxidants and lipid peroxidation, and histopathological changes in cardiac and hepatic tissue. Conclusion: Thus, the present study provides the first scientific evidence for a protective role of ARCE against ATH diet-induced hypercholesterolaemia and cardiac and hepatic oxidative stress.

Original languageEnglish (US)
Pages (from-to)1688-1693
Number of pages6
JournalJournal of the Science of Food and Agriculture
Volume92
Issue number8
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Atherogenic Diet
Anthocyanins
Brassica
Brassica oleracea
cabbage
anthocyanins
Oxidative Stress
oxidative stress
liver
Liver
rats
extracts
diet
Hypercholesterolemia
hypercholesterolemia
Antioxidants
Lipids
cardioprotective effect
antioxidants
hepatoprotective effect

Keywords

  • Brassica oleracea L.
  • Histopathology
  • Hypercholesteolaemia
  • Oxidative stress

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Agronomy and Crop Science
  • Nutrition and Dietetics

Cite this

Anthocyanin-rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet. / Sankhari, Jayanta M.; Thounaojam, Menaka; Jadeja, Ravirajsinh N.; Devkar, Ranjitsinh V.; Ramachandran, A. V.

In: Journal of the Science of Food and Agriculture, Vol. 92, No. 8, 01.06.2012, p. 1688-1693.

Research output: Contribution to journalArticle

Sankhari, Jayanta M. ; Thounaojam, Menaka ; Jadeja, Ravirajsinh N. ; Devkar, Ranjitsinh V. ; Ramachandran, A. V. / Anthocyanin-rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet. In: Journal of the Science of Food and Agriculture. 2012 ; Vol. 92, No. 8. pp. 1688-1693.
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