Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin

Kanjana Jittiporn, Jutamas Suwanpradid, Chintan Patel, Modesto Rojas, Suwan Thirawarapan, Primchanien Moongkarndi, Wisuda Suvitayavat, Ruth B. Caldwell

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Retinal neovascularization is a major cause of vision loss in diseases characterized by retinal ischemia and is characterized by the pathological growth of abnormal vessels. Vascular endothelial growth factor (VEGF) is known to play an important role in this process. Oxidative stress has been strongly implicated in up-regulation of VEGF associated with neovascularization in various tissues. Hence, compounds with anti-oxidant actions can prevent neovascularization. α-Mangostin, a component of mangosteen (. Garcinia mangostana Linn), has been shown to have an anti-oxidant property in pathological conditions involving angiogenesis such as cancer. However, the effect of α-mangostin on ROS formation and angiogenic function in microvascular endothelial cells has not been studied. Hence, this study demonstrated the anti-angiogenic effects of α-mangostin in relation to ROS formation in bovine retinal endothelial cells (REC). α-Mangostin significantly and dose-dependently reduced formation of ROS in hypoxia-treated REC. α-Mangostin also significantly and dose-dependently suppressed VEGF-induced increases in permeability, proliferation, migration and tube formation in REC and blocked angiogenic sprouting in the ex vivo aortic ring assay. In addition, α-mangostin inhibited VEGF-induced phosphorylation of VEGFR2 and ERK1/2-MAPK. According to our results, α-mangostin reduces oxidative stress and limits VEGF-induced angiogenesis through a process involving abrogation of VEGFR2 and ERK1/2-MAPK activation.

Original languageEnglish (US)
Pages (from-to)72-79
Number of pages8
JournalMicrovascular Research
Volume93
DOIs
StatePublished - May 2014

Fingerprint

Garcinia mangostana
Xanthones
Vascular Endothelial Growth Factor A
Endothelial cells
Endothelial Cells
Oxidative stress
Oxidants
Oxidative Stress
Garcinia
Retinal Neovascularization
Retinal Diseases
Phosphorylation
mangostin
Permeability
Assays
Up-Regulation
Ischemia
Chemical activation
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin. / Jittiporn, Kanjana; Suwanpradid, Jutamas; Patel, Chintan; Rojas, Modesto; Thirawarapan, Suwan; Moongkarndi, Primchanien; Suvitayavat, Wisuda; Caldwell, Ruth B.

In: Microvascular Research, Vol. 93, 05.2014, p. 72-79.

Research output: Contribution to journalArticle

Jittiporn, K, Suwanpradid, J, Patel, C, Rojas, M, Thirawarapan, S, Moongkarndi, P, Suvitayavat, W & Caldwell, RB 2014, 'Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin', Microvascular Research, vol. 93, pp. 72-79. https://doi.org/10.1016/j.mvr.2014.03.005
Jittiporn, Kanjana ; Suwanpradid, Jutamas ; Patel, Chintan ; Rojas, Modesto ; Thirawarapan, Suwan ; Moongkarndi, Primchanien ; Suvitayavat, Wisuda ; Caldwell, Ruth B. / Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin. In: Microvascular Research. 2014 ; Vol. 93. pp. 72-79.
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