Anti-Ata in a renal transplant candidate: A case report

J. Gao, S. Wise, S. H. Tinsley, J. F. Shikle

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with end-stage renal disease on chronic dialysis was admitted to the hospital for renal transplantation evaluation. Blood type and antibody detection tests were performed. The antibody detection test results were positive. Initial antibody identification studies indicated the presence of a panagglutinin. The patient s autocontrol was negative. The antibody was subsequently iden-Tified by a reference laboratory as anti-Ata (Augustine), which is an extremely rare antibody due to the high prevalence of Ata in the general population. A monocyte monolayer assay (MMA) was performed to assess the clinical significance of the antibody in the event that blood was needed for transfusion, and At(a-) RBCs were not available. The MMA results predicted the antibody to be capable of causing hemolysis in vivo. A brief historical review of the incidence and clinical significance of this antibody is included in this case report. Immunohematology 2020;36:104-107.

Original languageEnglish (US)
Pages (from-to)104-107
Number of pages4
JournalImmunohematology
Volume36
Issue number3
DOIs
StatePublished - 2020

Keywords

  • Ata
  • Augustine blood group system
  • monocyte monolayer assay (MMA)
  • polyethylene glycol (PEG)
  • renal trans-plantation

ASJC Scopus subject areas

  • Medicine(all)

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